CASP1 - caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
Entrez Gene Name: caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
Entrez GeneID: Human(834)
, Mouse(12362), Rat(25166)
, Mouse(12362), Rat(25166) Synonyms: CASP1, CASPASE-1, ICE, IL1BC, interleukin 1-beta convertase, interleukin-1beta converting enzyme, P45, p45 ICE
Gene Summary
- Human (834): This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. [provided by RefSeq]
- Rat (25166): apoptotic protease that may play a role in inflammation and apoptosis in male sex organs [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
apoptosis, cell death, induction of apoptosis, positive regulation of cytokine secretion, positive regulation of I-kappaB kinase/NF-kappaB cascade, positive regulation of interleukin-1 alpha secretion, positive regulation of interleukin-1 beta secretion, protein processing, proteolysis, regulation of apoptosis, response to ATP, response to chemical stimulus, response to hypoxia, signal transduction
Literature References
- 18329368Keller M, Ruegg A, Werner S, Beer HD. Active caspase-1 is a regulator of unconventional protein secretion.Cell 2008 03 7;132(5):818-31
- 17452523Henry T, Brotcke A, Weiss DS, Thompson LJ, Monack DM. Type I interferon signaling is required for activation of the inflammasome during Francisella infection.J Exp Med 2007 May 14;204(5):987-94
- 16286013Dinarello CA. An IL-1 Family Member Requires Caspase-1 Processing and Signals through the ST2 Receptor.Immunity 2005 Nov 01;23(5):461-2 View 3048 categorized literature findings and their references in IPA
Molecular Functions
caspase activator activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity, protein binding
Protein Domains
Card domain, caspase, caspase activator, caspase domain, Cysteine endopeptidase, peptidase, pro domain, protein binding
