P2RX2 - purinergic receptor P2X, ligand-gated ion channel, 2
Entrez Gene Name: purinergic receptor P2X, ligand-gated ion channel, 2
Entrez GeneID: Human(22953)
, Mouse(231602), Rat(114115)
, Mouse(231602), Rat(114115) Synonyms: MGC129148, MGC129149, MGC129601, P2RX2, P2X2, P2X2A
Gene Summary
- Human (22953): The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for this gene. [provided by RefSeq]
- Rat (114115): subunits assemble into ATP-gated ion channels involved in neuritogenesis and cell survival [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
behavioral response to pain, detection of hypoxic conditions in blood by carotid body chemoreceptor signaling, ion transport, neuromuscular junction development, neuromuscular synaptic transmission, peristalsis, positive regulation of calcium ion transport into cytosol, positive regulation of calcium-mediated signaling, protein heterooligomerization, protein homooligomerization, regulation of action potential in neuron, response to ATP, response to carbohydrate stimulus, response to hypoxia, response to organic substance, sensory perception of taste, skeletal muscle fiber development, synaptic transmission, transport, urinary bladder smooth muscle contraction
Cellular Components
cell soma, dendritic spine, integral to membrane, intracellular part, membrane, membrane fraction, plasma membrane, postsynaptic density, presynaptic membrane, terminal button
Literature References
- 18487206Roberts JA, Digby HR, Kara M, Ajouz SE, Sutcliffe MJ, Evans RJ. Cysteine Substitution Mutagenesis and the Effects of Methanethiosulfonate Reagents at P2X2 and P2X4 Receptors Support a Core Common Mode of ATP Action at P2X Receptors.J Biol Chem 2008 Jul 18;283(29):20126-36
- 17895406Dubyak GR. Go It Alone No More P2X7 Joins the Society of Heteromeric ATP-Gated Receptor Channels.Mol Pharmacol 2007 Dec 01;72(6):1402-5
- 18032665Cao L, Young MT, Broomhead HE, Fountain SJ, North RA. Thr339-to-Serine Substitution in Rat P2X2 Receptor Second Transmembrane Domain Causes Constitutive Opening and Indicates a Gating Role for Lys308.J Neurosci 2007 Nov 21;27(47):12916-23 View 267 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, ATP-gated cation channel activity, cadmium ion binding, cobalt ion binding, copper ion binding, drug binding, ion channel activity, ligand-gated ion channel activity, mercury ion binding, nickel ion binding, phosphoinositide binding, protein binding, protein heterodimerization activity, protein homodimerization activity, purinergic nucleotide receptor activity, receptor activity, zinc ion binding
Protein Domains
ATP binding, ATP-gated cation channel, cadmium ion binding, copper ion binding, cytosolic tail domain, drug binding, ion channel, ligand-gated ion channel, mercury ion binding, N-terminal domain, nickel ion binding, protein binding, zinc ion binding
Subcellular Locations
axon terminals, cell body, cell surface, cellular membrane, clathrin-coated vesicles, cytoplasm, dendrites, dendritic spines, endoplasmic reticulum membrane, neurites, plasma membrane, postsynaptic density, smooth microsomes
