PDGFRB - platelet-derived growth factor receptor, beta polypeptide
Entrez Gene Name: platelet-derived growth factor receptor, beta polypeptide
Entrez GeneID: Human(5159)
, Mouse(18596), Rat(24629)
, Mouse(18596), Rat(24629) Synonyms: AI528809, CD140B, JTK12, PDGF BETA-RECEPTOR, PDGF RECEPTOR BETA, PDGF-R-BETA, PDGFR, PDGFR1, PDGFRB
Gene Summary
- Human (5159): This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq]
- Rat (24629): binds platelet derived growth factor BB homodimer [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cell chemotaxis, glycosaminoglycan biosynthetic process, in utero embryonic development, inner ear development, kidney development, nitrogen compound metabolic process, platelet-derived growth factor receptor signaling pathway, positive regulation of anti-apoptosis, positive regulation of cell migration, positive regulation of cell proliferation, positive regulation of collagen biosynthetic process, protein amino acid autophosphorylation, protein amino acid phosphorylation, protein kinase cascade, regulation of peptidyl-tyrosine phosphorylation, response to estradiol stimulus, response to estrogen stimulus, response to fluid shear stress, response to hydrogen peroxide, response to hyperoxia, response to lipid, response to organic cyclic substance, response to retinoic acid, response to toxin, signal transduction, skeletal system morphogenesis, smooth muscle tissue development, tissue homeostasis, transforming growth factor beta receptor signaling pathway, transmembrane receptor protein tyrosine kinase signaling pathway, wound healing
Literature References
- 15889147Kiyan J, Kiyan R, Haller H, Dumler I. Urokinase-induced signaling in human vascular smooth muscle cells is mediated by PDGFR-beta.EMBO J 2005 May 18;24(10):1787-97
- 16456542Takahashi Y, Morales FC, Kreimann EL, Georgescu MM. PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling.EMBO J 2006 02 22;25(4):910-20
- 16037818Silva RL, Thornton JD, Martin AC, Rehg JE, Bertwistle D, Zindy F, Skapek SX. Arf-dependent regulation of Pdgf signaling in perivascular cells in the developing mouse eye.EMBO J 2005 Aug 03;24(15):2803-14 View 2670 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, kinase activity, nucleotide binding, platelet activating factor receptor activity, platelet-derived growth factor beta-receptor activity, platelet-derived growth factor binding, platelet-derived growth factor receptor activity, platelet-derived growth factor receptor binding, protein binding, protein kinase activity, protein tyrosine kinase activity, receptor activity, signal transducer activity, transferase activity, transmembrane receptor protein tyrosine kinase activity, vascular endothelial growth factor receptor activity
Protein Domains
autophosphorylation site, cytoplasmic domain, extracellular domain, immunoglobulin domain, juxtamembrane domain, kinase, PDZ binding motif, PI3K binding domain, platelet activating factor receptor, platelet-derived growth factor receptor, platelet-derived growth factor receptor beta, platelet-derived growth factor receptor binding, PLC gamma1 protein binding domain, protein binding, Protein kinase, protein-tyrosine kinase, signal transducer, transmembrane domain, tyrosine kinase domain
Subcellular Locations
apical membrane, caveolae fraction, cell surface, cellular membrane, cytoplasm, cytosol, perinuclear region, plasma membrane, raft fractions, ruffled borders
