BCHE - butyrylcholinesterase
Entrez Gene Name: butyrylcholinesterase
Entrez GeneID: Human(590)
, Mouse(12038), Rat(65036)
, Mouse(12038), Rat(65036) Synonyms: BCHE, BUCHE, Butyrylcholine esterase, BUTYRYLCHOLINESTERASE, C730038G20Rik, CHE1, E1, MGC107651
Gene Summary
- Human (590): Mutant alleles at the BCHE locus are responsible for suxamethonium sensitivity. Homozygous persons sustain prolonged apnea after administration of the muscle relaxant suxamethonium in connection with surgical anesthesia. The activity of pseudocholinesterase in the serum is low and its substrate behavior is atypical. In the absence of the relaxant, the homozygote is at no known disadvantage. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
choline metabolic process, cocaine metabolic process, learning, negative regulation of synaptic transmission, response to alkaloid, response to drug, response to folic acid, response to glucocorticoid stimulus, response to nutrient
Cellular Components
endoplasmic reticulum, endoplasmic reticulum lumen, extracellular region, extracellular space, membrane, membrane fraction, nuclear envelope lumen
Literature References
- 10700174Ross DT, Scherf U, Eisen MB, Perou CM, Rees C, Spellman P, Iyer V, Jeffrey SS, Van de Rijn M, Waltham M, Pergamenschikov A, Lee JC, Lashkari D, Shalon D, Myers TG, Weinstein JN, Botstein D, Brown PO. Systematic variation in gene expression patterns in human cancer cell lines [see comments]Nat Genet 2000 Mar;24(3):227-35
- 10529218Altamirano CV, Lockridge O. Conserved aromatic residues of the C-terminus of human butyrylcholinesterase mediate the association of tetramers.Biochemistry 1999 Oct 5;38(40):13414-22
- 9398183Saxena A, Redman AM, Jiang X, Lockridge O, Doctor BP. Differences in active site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase.Biochemistry 1997 Dec 2;36(48):14642-51 View 144 categorized literature findings and their references in IPA
Molecular Functions
beta-amyloid binding, carboxylesterase activity, choline binding, cholinesterase activity, enzyme binding, hydrolase activity
