PRKCE - protein kinase C, epsilon
Entrez Gene Name: protein kinase C, epsilon
Entrez GeneID: Human(5581)
, Mouse(18754), Rat(29340)
, Mouse(18754), Rat(29340) Synonyms: 5830406C15RIK, MGC125656, MGC125657, nPKC-epsilon, PKC EPSILON, PKC E , PKCE, PRKCE, R75156
Gene Summary
- Human (5581): Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq]
- Rat (29340): has phospholipid and diacylglycerol-dependent activity; plays a role in ouabain induced Na+/K+-ATPase mediated signal transduction in cardiac myocytes [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
chemosensory behavior, induction of apoptosis, intracellular signaling cascade, protein amino acid phosphorylation, regulation of peptidyl-tyrosine phosphorylation
Literature References
- 10836144Sah VP, Seasholtz TM, Sagi SA, Brown JH. The role of Rho in G protein-coupled receptor signal transduction.Annu Rev Pharmacol Toxicol 2000;40:459-89
- 17554300Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.Nature 2007 06 7;447(7145):661-78
- 10677042Khasar SG, Lin YH, Martin A, Dadgar J, McMahon T, Wang D, Hundle B, Aley KO, Isenberg W, McCarter G, Green PG, Hodge CW, Levine JD, Messing RO. A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice.Neuron 1999 Sep 1;24(1):253-60 View 4766 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, calcium-independent protein kinase C activity, diacylglycerol binding, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein kinase C activity, protein serine/threonine kinase activity, signal transducer activity, transferase activity, zinc ion binding
- α-Adrenergic Signaling
- Corticotropin Releasing Hormone Signaling
- GNRH Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Endothelin-1 Signaling
- G-Protein Coupled Receptor Signaling
- Huntington's Disease Signaling
- Virus Entry via Endocytic Pathways
- mTOR Signaling
- Axonal Guidance Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- G Beta Gamma Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- Leukocyte Extravasation Signaling
- VDR/RXR Activation
- NF-κB Activation by Viruses
- Prolactin Signaling
- Androgen Signaling
- Neuregulin Signaling
- Apoptosis Signaling
- Erythropoietin Signaling
- IL-8 Signaling
- Natural Killer Cell Signaling
- Hepatic Cholestasis
- LPS-stimulated MAPK Signaling
- Calcium-induced T Lymphocyte Apoptosis
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- ERK/MAPK Signaling
- Xenobiotic Metabolism Signaling
- Glioma Signaling
- Inositol Phosphate Metabolism
- RAR Activation
- CCR3 Signaling in Eosinophils
- Macropinocytosis Signaling
- Aldosterone Signaling in Epithelial Cells
- Growth Hormone Signaling
- Renin-Angiotensin Signaling
- CREB Signaling in Neurons
- p70S6K Signaling
- Melatonin Signaling
- Thrombopoietin Signaling
- Thrombin Signaling
- Synaptic Long Term Depression
- IL-3 Signaling
- Nicotinate and Nicotinamide Metabolism
- Amyloid Processing
- Synaptic Long Term Potentiation
- Molecular Mechanisms of Cancer
- Mechanisms of Viral Exit from Host Cells
- CXCR4 Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Fc Epsilon RI Signaling
- CCR5 Signaling in Macrophages
- NRF2-mediated Oxidative Stress Response
- 14-3-3-mediated Signaling
- fMLP Signaling in Neutrophils
- Type II Diabetes Mellitus Signaling
- HGF Signaling
- IL-12 Signaling and Production in Macrophages
Protein Domains
Alcohol group acceptor phosphotransferase, C1 domain, C1A domain, C1B domain, C2 domain, calcium independent protein kinase C, catalytic domain, hydrophobic domain, kinase, protein binding, Protein kinase, protein serine/threonine kinase, pseudosubstrate domain, regulatory domain, signal transducer
Subcellular Locations
cell periphery, cell-cell contacts, cellular membrane, cytoplasm, cytoplasmic fraction, cytoplasmic vesicles, cytoskeleton, cytosol, cytosolic fraction, intracellular space, membrane fraction, microsomal fraction, mitochondria, neurites, nucleus, perinuclear region, plasma membrane, sarcolemma, soluble fraction, vesicles
