E2F5 - E2F transcription factor 5, p130-binding
Entrez Gene Name: E2F transcription factor 5, p130-binding
Entrez GeneID: Human(1875)
, Mouse(13559), Rat(116651)
, Mouse(13559), Rat(116651) Synonyms: AU024671, E2F5
Gene Summary
- Human (1875): The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq]
- Rat (116651): transcription factor implicated in the regulation of genes associated with cell cycle progression [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
G1/S transition of mitotic cell cycle, organ morphogenesis, regulation of cell cycle, regulation of transcription, DNA-dependent, transcription
Cellular Components
cytoplasm, nuclear envelope, nucleoplasm, nucleus, sarcoplasm, transcription factor complex
Literature References
- 11799066Weinmann AS, Yan PS, Oberley MJ, Huang TH, Farnham PJ. Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis.Genes Dev 2002 Jan 15;16(2):235-44
- 10727462Halaban R, Cheng E, Smicun Y, Germino J. Deregulated E2F transcriptional activity in autonomously growing melanoma cells.J Exp Med 2000 Mar 20;191(6):1005-16
- 15502875John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets.PLoS Biol 2004 11 1;2(11):e363 View 971 categorized literature findings and their references in IPA
Molecular Functions
DNA binding, ion channel activity, protein binding, sequence-specific DNA binding, transcription factor activity
