P2RY11 - purinergic receptor P2Y, G-protein coupled, 11
Entrez Gene Name: purinergic receptor P2Y, G-protein coupled, 11
Entrez GeneID: Human(5032)
Synonyms: P2RY11, P2Y11
Gene Summary
- Human (5032): The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Regulated by:
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Biological Process
activation of adenylate cyclase activity, activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger, defense response, signal transduction
Literature References
- 12743035Gschwind A, Hart S, Fischer OM, Ullrich A. TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells.EMBO J 2003 May 15;22(10):2411-2421
- 12130504Idzko M, Dichmann S, Ferrari D, Di Virgilio F, la Sala A, Girolomoni G, Panther E, Norgauer J. Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors.Blood 2002 Aug 1;100(3):925-32
- 11116131van Der Weyden L, Adams DJ, Morris BJ. Capacity for purinergic control of renin promoter via P2Y(11) receptor and cAMP pathways.Hypertension 2000 Dec 1;36(6):1093-8 View 138 categorized literature findings and their references in IPA
Molecular Functions
G-protein coupled receptor activity, purinergic nucleotide receptor activity, G-protein coupled, receptor activity
