ADRA2A - adrenergic, alpha-2A-, receptor
Entrez Gene Name: adrenergic, alpha-2A-, receptor
Entrez GeneID: Human(150)
, Mouse(11551), Rat(25083)
, Mouse(11551), Rat(25083) Synonyms: ADRA-2, ADRA2A, ADRA2R, ADRAR, ADRENOCEPTOR ALPHA2A, alpha(2A)AR, ALPHA-2A ADRENERGIC RECEPTOR, ALPHA2-C10, alpha2A, Alpha2a Adrenoceptor, ALPHA2A-AR, AW122659, RATRG20, RG20, ZNF32
Gene Summary
- Human (150): Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
actin cytoskeleton organization, activation of MAPK activity, cell motion, DNA replication, fear response, G-protein coupled receptor protein signaling pathway, negative regulation of adenylate cyclase activity, positive regulation of cell proliferation, Rho protein signal transduction, signal transduction
Cellular Components
cytoplasm, integral to membrane, integral to plasma membrane, membrane, plasma membrane, synapse
Literature References
- 12068299Philipp M, Brede ME, Hadamek K, Gessler M, Lohse MJ, Hein L. Placental alpha(2)-adrenoceptors control vascular development at the interface between mother and embryo.Nat Genet 2002 Jul 1;31(3):311-5
- 16371464Gibson SK, Gilman AG. Gi{alpha} and G{beta} subunits both define selectivity of G protein activation by {alpha}2-adrenergic receptors.Proc Natl Acad Sci U S A 2006 Jan 03;103(1):212-7
- 16033418Bauer A, Zilles K, Matusch A, Holzmann C, Riess O, von Hörsten S. Regional and subtype selective changes of neurotransmitter receptor density in a rat transgenic for the Huntington's disease mutation.J Neurochem 2005 Aug 01;94(3):639-50 View 821 categorized literature findings and their references in IPA
Molecular Functions
adrenoceptor activity, alpha2-adrenergic receptor activity, G-protein coupled receptor activity, potassium channel regulator activity, protein binding, receptor activity, signal transducer activity
Protein Domains
adrenoceptor, alpha2-adrenergic receptor, G-protein coupled receptor, intracellular loop, potassium channel regulator, protein binding
