HTR2A - 5-hydroxytryptamine (serotonin) receptor 2A
Entrez Gene Name: 5-hydroxytryptamine (serotonin) receptor 2A
Entrez GeneID: Human(3356)
, Mouse(15558), Rat(29595)
, Mouse(15558), Rat(29595) Synonyms: 5-HT 2A RECEPTOR, 5-HT2A, 5Ht-2, E030013E04, HTR2, HTR2A, MGC124301, MGC124302
Gene Summary
- Rat (29595): a receptor for 5-hydroxytryptamine (serotonin); activates phospholipase C signaling pathway; involved in promoting cellular transformation [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of phospholipase C activity by serotonin receptor signaling pathway, aging, cell death, G-protein coupled receptor protein signaling pathway, memory, negative regulation of potassium ion transport, negative regulation of synaptic transmission, glutamatergic, positive regulation of cell proliferation, positive regulation of MAP kinase activity, positive regulation of vasoconstriction, regulation of dopamine secretion, response to drug, response to stress, sensory perception of pain, signal transduction, sleep, synaptic transmission, temperature homeostasis
Cellular Components
cytoplasm, dendrite, dendritic shaft, integral to membrane, integral to plasma membrane, membrane, plasma membrane
Literature References
- 12743035Gschwind A, Hart S, Fischer OM, Ullrich A. TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells.EMBO J 2003 May 15;22(10):2411-2421
- 17329232Carter CJ. EIF2B and Oligodendrocyte Survival: Where Nature and Nurture Meet in Bipolar Disorder and Schizophrenia?Schizophr Bull 2007 Nov 01;33(6):1343-53
- 17000863Braden MR, Parrish JC, Naylor JC, Nichols DE. Molecular Interaction of Serotonin 5-HT2A Receptor Residues Phe339(6.51) and Phe340(6.52) with Superpotent N-Benzyl Phenethylamine Agonists.Mol Pharmacol 2006 Dec 01;70(6):1956-64 View 848 categorized literature findings and their references in IPA
Molecular Functions
G-protein coupled receptor activity, protein complex binding, receptor activity, serotonin binding, serotonin receptor activity, signal transducer activity
Protein Domains
carboxy terminal domain, G-protein coupled receptor, intracellular loop, PDZ binding motif, serotonin receptor
Subcellular Locations
caveolae fraction, cell body, cell surface, cellular membrane, cytoplasm, dendrites, granules, intracellular membranes, membrane fraction, perinuclear membrane, plasma membrane, synaptic membrane, transverse tubules
