CCK - cholecystokinin
Entrez Gene Name: cholecystokinin
Entrez GeneID: Human(885)
, Mouse(12424), Rat(25298)
, Mouse(12424), Rat(25298) Synonyms: CCK, CCK8, CHOLECYSTOKININ, Cholecystokinin 8, MGC117187
Gene Summary
- Human (885): Cholecystokinin is a brain/gut peptide. In the gut, it induces the release of pancreatic enzymes and the contraction of the gallbladder. In the brain, its physiologic role is unclear. The cholecystokinin pro-hormone is processed by endo- and exo-proteolytic cleavages. [provided by RefSeq]
- Rat (25298): brain-gut peptide with hemacrine and autocrine function in the gut [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of caspase activity, activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway, apoptosis, axonogenesis, behavioral fear response, eating behavior, negative regulation of appetite, neuron migration, positive regulation of apoptosis, positive regulation of mitochondrial depolarization, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of protein oligomerization, regulation of sensory perception of pain, release of cytochrome c from mitochondria, signal transduction
Cellular Components
axon, axon hillock, cell soma, dendrite, extracellular region, extracellular space, initial segment, perikaryon, terminal button
Literature References
- 17324928Cosen-Binker LI, Lam PP, Binker MG, Reeve J, Pandol S, Gaisano HY. Alcohol/Cholecystokinin-evoked Pancreatic Acinar Basolateral Exocytosis Is Mediated by Protein Kinase C{alpha} Phosphorylation of Munc18c.J Biol Chem 2007 Apr 27;282(17):13047-58
- 16174778Beinfeld MC, Blum A, Vishnuvardhan D, Fanous S, Marchand JE. Cholecystokinin Levels in Prohormone Convertase 2 Knock-out Mouse Brain Regions Reveal a Complex Phenotype of Region-specific Alterations.J Biol Chem 2005 Nov 18;280(46):38410-5
- 16093397Tsujino N, Yamanaka A, Ichiki K, Muraki Y, Kilduff TS, Yagami K, Takahashi S, Goto K, Sakurai T. Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor.J Neurosci 2005 Aug 10;25(32):7459-69 View 850 categorized literature findings and their references in IPA
Subcellular Locations
axon terminals, cell surface, cellular membrane, cytoplasm, cytosol, extracellular space, nerve ending, perikaryon, plasma membrane, plasma membrane fraction, presynaptic terminals, vesicle fraction
