GABRB1 - gamma-aminobutyric acid (GABA) A receptor, beta 1
Entrez Gene Name: gamma-aminobutyric acid (GABA) A receptor, beta 1
Entrez GeneID: Human(2560)
, Mouse(14400), Rat(25450)
, Mouse(14400), Rat(25450) Synonyms: AW061132, B230208N19RIK, GABA A RECEPTOR SUBUNIT BETA1, GABRB1, GARB1
Gene Summary
- Human (2560): The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia. [provided by RefSeq]
- Rat (25450): subunit of GABAA receptors,which induce inhibitory postsynaptic currents; may regulate synaptic transmission in the prefrontal cortex [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Role in cell:
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Biological Process
chloride transport, gamma-aminobutyric acid signaling pathway, ion transport, signal transduction, transport
Cellular Components
cell junction, integral to membrane, integral to plasma membrane, membrane, plasma membrane, postsynaptic membrane, synapse
Literature References
- 17554300Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.Nature 2007 06 7;447(7145):661-78
- 12151513Brandon NJ, Jovanovic JN, Smart TG, Moss SJ. Receptor for activated C kinase-1 facilitates protein kinase C-dependent phosphorylation and functional modulation of GABA(A) receptors with the activation of G-protein-coupled receptors.J Neurosci 2002 Aug 1;22(15):6353-61
- 8183949Wingrove PB, Wafford KA, Bain C, Whiting PJ. The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit.Proc Natl Acad Sci U S A 1994 May 10;91(10):4569-73 View 206 categorized literature findings and their references in IPA
Molecular Functions
chloride channel activity, chloride ion binding, extracellular ligand-gated ion channel activity, GABA-A receptor activity, ion channel activity, ligand-gated ion channel activity, neurotransmitter receptor activity, receptor activity
Protein Domains
extracellular ligand binding domain, GABA-A receptor, intracellular domain, intracellular loop, ion channel, ligand-gated ion channel, neurotransmitter-gated ion channel ligand binding domain
