LAIR1 - leukocyte-associated immunoglobulin-like receptor 1
Entrez Gene Name: leukocyte-associated immunoglobulin-like receptor 1
Entrez GeneID: Human(3903)
, Mouse(52855), Rat(574531)
, Mouse(52855), Rat(574531) Synonyms: 5133400O11Rik, BB115266, CD305, D7Bwg0421e, LAIR1, mLair-1
Gene Summary
- Human (3903): The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
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Literature References
- 16754721Lebbink RJ, de Ruiter T, Adelmeijer J, Brenkman AB, van Helvoort JM, Koch M, Farndale RW, Lisman T, Sonnenberg A, Lenting PJ, Meyaard L. Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1.J Exp Med 2006 Jun 12;203(6):1419-25
- 9285412Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland GR, Lanier LL, Phillips JH. LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes.Immunity 1997 Aug 1;7(2):283-90
- 11435477Meyaard L, van der Vuurst de Vries AR, de Ruiter T, Lanier LL, Phillips JH, Clevers H. The epithelial cellular adhesion molecule (Ep-CAM) is a ligand for the leukocyte-associated immunoglobulin-like receptor (LAIR).J Exp Med 2001 Jul 2;194(1):107-12 View 160 categorized literature findings and their references in IPA
Protein Domains
extracellular domain, intracellular domain, protein binding, transmembrane domain, transmembrane receptor
