CASP3 - caspase 3, apoptosis-related cysteine peptidase
Entrez Gene Name: caspase 3, apoptosis-related cysteine peptidase
Entrez GeneID: Human(836)
, Mouse(12367), Rat(25402)
, Mouse(12367), Rat(25402) Synonyms: A830040C14Rik, Apopain, CASP3, CASPASE-3, CASPASE-3 p20, CC3, CPP32, CPP32B, Cpp32beta, Ice-like cysteine protease, Lice, MGC93645, P17, PROCASPASE 3, SCA-1, YAMA
Gene Summary
- Human (836): This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq]
- Rat (25402): apoptotic cysteine-aspartic acid protease that may play a role in neuronal cell death regulation and other apoptotic processes [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
apoptosis, B cell homeostasis, cell fate commitment, DNA fragmentation involved in apoptosis, heart development, hippocampus development, induction of apoptosis, induction of apoptosis by oxidative stress, induction of apoptosis via death domain receptors, intracellular signaling cascade, keratinocyte differentiation, learning or memory, negative regulation of activated T cell proliferation, negative regulation of apoptosis, negative regulation of B cell proliferation, negative regulation of cell cycle, negative regulation of cyclin-dependent protein kinase activity, neuron apoptosis, neuron differentiation, nuclear fragmentation during apoptosis, positive regulation of neuron apoptosis, proteolysis, release of cytochrome c from mitochondria, response to amino acid stimulus, response to DNA damage stimulus, response to drug, response to glucocorticoid stimulus, response to hydrogen peroxide, response to hypoxia, response to lipopolysaccharide, response to metal ion, response to organic cyclic substance, response to organic substance, response to tumor necrosis factor, response to UV, response to wounding, response to X-ray, sensory perception of sound, T cell homeostasis, wound healing
Cellular Components
cytoplasm, cytosol, mitochondrion, nucleolus, nucleoplasm, nucleus, plasma membrane, soluble fraction
Literature References
- 17124493Zhang Y, Leavitt BR, van Raamsdonk JM, Dragatsis I, Goldowitz D, Macdonald ME, Hayden MR, Friedlander RM. Huntingtin inhibits caspase-3 activation.EMBO J 2006 Dec 13;25(24):5896-906
- 14556717Yuan J, Lipinski M, Degterev A. Diversity in the mechanisms of neuronal cell death.Neuron 2003 Oct 09;40(2):401-13
- 12874265Kashkar H, Haefs C, Shin H, Hamilton-Dutoit SJ, Salvesen GS, Kronke M, Jurgensmeier JM. XIAP-mediated caspase inhibition in Hodgkin's lymphoma-derived B cells.J Exp Med 2003 Jul 21;198(2):341-7 View 8580 categorized literature findings and their references in IPA
Molecular Functions
cyclin-dependent protein kinase inhibitor activity, cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity, phospholipase A2 activator activity, protein binding
- Sphingosine-1-phosphate Signaling
- Lymphotoxin β Receptor Signaling
- Lysine Degradation
- Retinoic acid Mediated Apoptosis Signaling
- Endothelin-1 Signaling
- Death Receptor Signaling
- Induction of Apoptosis by HIV1
- Endoplasmic Reticulum Stress Pathway
- Type I Diabetes Mellitus Signaling
- Docosahexaenoic Acid (DHA) Signaling
- CD27 Signaling in Lymphocytes
- PTEN Signaling
- Colorectal Cancer Metastasis Signaling
- Molecular Mechanisms of Cancer
- Parkinson's Signaling
- Apoptosis Signaling
- Mitochondrial Dysfunction
- Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells
- Amyotrophic Lateral Sclerosis Signaling
- Myc Mediated Apoptosis Signaling
- Role of PKR in Interferon Induction and Antiviral Response
- Huntington's Disease Signaling
Protein Domains
carboxy terminal domain, caspase domain, cyclin-dependent protein kinase inhibitor, Cysteine endopeptidase, cysteine-type peptidase, peptidase, phospholipase A2 activator, protein binding
Subcellular Locations
axons, cellular membrane, centrosome, cytoplasm, cytoplasmic fraction, cytosol, cytosolic fraction, dendrites, granules, membrane rafts, mitochondria, mitochondrial intermembrane space, nucleus, perikaryon, perinuclear region, residual bodies
