ADRA2B - adrenergic, alpha-2B-, receptor
Entrez Gene Name: adrenergic, alpha-2B-, receptor
Entrez GeneID: Human(151)
, Mouse(11552), Rat(24174)
, Mouse(11552), Rat(24174) Synonyms: a 2B, ADRA2B, ADRA2L1, ADRA2RL1, ADRARL1, ALPHA 2B ADRENERGIC RECEPTOR, alpha2-C2, ALPHA2-C2-AR, alpha2B, Alpha2b Adrenoceptor, ALPHA2BAR
Gene Summary
- Human (151): Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. This gene encodes the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. This gene contains no introns in either its coding or untranslated sequences. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of MAPK activity, angiogenesis, cell-cell signaling, G-protein coupled receptor protein signaling pathway, MAPKKK cascade, signal transduction
Literature References
- 12068299Philipp M, Brede ME, Hadamek K, Gessler M, Lohse MJ, Hein L. Placental alpha(2)-adrenoceptors control vascular development at the interface between mother and embryo.Nat Genet 2002 Jul 1;31(3):311-5
- 16371464Gibson SK, Gilman AG. Gi{alpha} and G{beta} subunits both define selectivity of G protein activation by {alpha}2-adrenergic receptors.Proc Natl Acad Sci U S A 2006 Jan 03;103(1):212-7
- 16033418Bauer A, Zilles K, Matusch A, Holzmann C, Riess O, von Hörsten S. Regional and subtype selective changes of neurotransmitter receptor density in a rat transgenic for the Huntington's disease mutation.J Neurochem 2005 Aug 01;94(3):639-50 View 714 categorized literature findings and their references in IPA
Molecular Functions
adrenoceptor activity, alpha2-adrenergic receptor activity, G-protein coupled receptor activity, protein binding, receptor activity, signal transducer activity
Protein Domains
adrenoceptor, alpha2-adrenergic receptor, G-protein coupled receptor, intracellular loop, protein binding
Subcellular Locations
basolateral cell surfaces, cell surface, cellular membrane, membrane fraction, plasma membrane
