HTR1B - 5-hydroxytryptamine (serotonin) receptor 1B
Entrez Gene Name: 5-hydroxytryptamine (serotonin) receptor 1B
Entrez GeneID: Human(3351)
, Mouse(15551), Rat(25075)
, Mouse(15551), Rat(25075) Synonyms: 5-HT1B, 5-HT1B RECEPTOR, 5-HT1DB, 5-hydroxytryptamine (serotonin) receptor 1B, 5HT1D BETA RECEPTOR, HTR1B, HTR1D2, HTR1DB, S12
Gene Summary
- Human (3351): The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of 4 main groups, 5-HT-1, 5-HT-2, 5-HT-3, and 5-HT4, subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system (Zifa and Fillion, 1992 [PubMed 1359584]). The serotonergic receptors belong to the multigene family of receptors coupled to guanine nucleotide-binding proteins.[supplied by OMIM]
- Rat (25075): G-protein coupled receptor for serotonin; may have a role in learning and memory [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
drinking behavior, feeding behavior, G-protein coupled receptor protein signaling pathway, G-protein signaling, coupled to cyclic nucleotide second messenger, negative regulation of cAMP biosynthetic process, negative regulation of synaptic transmission, GABAergic, negative regulation of synaptic transmission, glutamatergic, regulation of dopamine secretion, response to cocaine, response to ethanol, response to mineralocorticoid stimulus, response to toxin, signal transduction, synaptic transmission
Literature References
- 15502875John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets.PLoS Biol 2004 11 1;2(11):e363
- 12388666Millan MJ, Maiofiss L, Cussac D, Audinot V, Boutin JA, Newman-Tancredi A. Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes.J Pharmacol Exp Ther 2002 Nov 01;303(2):791-804
- 12388668Newman-Tancredi A, Cussac D, Quentric Y, Touzard M, Verriele L, Carpentier N, Millan MJ. Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. III. Agonist and antagonist properties at serotonin, 5-HT(1) and 5-HT(2), receptor subtypes.J Pharmacol Exp Ther 2002 Nov;303(2):815-22 View 349 categorized literature findings and their references in IPA
Molecular Functions
drug binding, G-protein coupled receptor activity, protein binding, receptor activity, serotonin binding, serotonin receptor activity, signal transducer activity
Protein Domains
cytoplasmic domain, drug binding, G-protein coupled receptor, intracellular loop, protein binding, serotonin receptor
