FGF4 - fibroblast growth factor 4
Entrez Gene Name: fibroblast growth factor 4
Entrez GeneID: Human(2249)
, Mouse(14175), Rat(116499)
, Mouse(14175), Rat(116499) Synonyms: FGF4, Fgfk, HBGF-4, HST, HST-1, HSTF1, K-FGF, KS3, MGC129266, MGC129267
Gene Summary
- Human (2249): The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq]
- Rat (116499): member of the fibroblast growth factor (FGF) family; implicated in activities including embryonic development, cell growth, morphogenesis, tissue growth, and tumor growth and invasion [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cartilage condensation, cell proliferation, cell-cell signaling, embryonic hindlimb morphogenesis, embryonic limb morphogenesis, fibroblast growth factor receptor signaling pathway, negative regulation of apoptosis, odontogenesis of dentine-containing tooth, positive regulation of cell proliferation, signal transduction, stem cell maintenance
Literature References
- 11101846Lewandoski M, Sun X, Martin GR. Fgf8 signalling from the AER is essential for normal limb development.Nat Genet 2000 Dec 1;26(4):460-3
- 7688944Fantl WJ, Johnson DE, Williams LT. Signalling by receptor tyrosine kinases.Annu Rev Biochem 1993;62:453-81
- 17537800Pajni-Underwood S, Wilson CP, Elder C, Mishina Y, Lewandoski M. BMP signals control limb bud interdigital programmed cell death by regulating FGF signaling.Development 2007 Jun 01;134(12):2359-68 View 479 categorized literature findings and their references in IPA
