GABRA4 - gamma-aminobutyric acid (GABA) A receptor, alpha 4
Entrez Gene Name: gamma-aminobutyric acid (GABA) A receptor, alpha 4
Entrez GeneID: Human(2557)
, Mouse(14397), Rat(140675)
, Mouse(14397), Rat(140675) Synonyms: GABAA receptor alpha4, GABRA4
Gene Summary
- Human (2557): GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq]
- Rat (140675): alpha 4 subunit of the GABA-A receptor which binds gamma-aminobutyric acid; involved in mood and anxiety [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Role in cell:
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Biological Process
chloride transport, gamma-aminobutyric acid signaling pathway, ion transport, transport
Cellular Components
cell junction, integral to membrane, integral to plasma membrane, membrane, plasma membrane, postsynaptic membrane, synapse
Literature References
- 15265862Ma L, Song L, Radoi GE, Harrison NL. Transcriptional regulation of the mouse gene encoding the alpha-4 subunit of the GABAA receptor.J Biol Chem 2004 Sep 24;279(39):40451-61
- 17554300Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.Nature 2007 06 7;447(7145):661-78
- 18032669Pignataro L, Miller AN, Ma L, Midha S, Protiva P, Herrera DG, Harrison NL. Alcohol regulates gene expression in neurons via activation of heat shock factor 1.J Neurosci 2007 Nov 21;27(47):12957-66 View 199 categorized literature findings and their references in IPA
Molecular Functions
benzodiazepine receptor activity, chloride channel activity, chloride ion binding, extracellular ligand-gated ion channel activity, GABA-A receptor activity, ion channel activity, neurotransmitter receptor activity, receptor activity
Protein Domains
benzodiazepine receptor, extracellular ligand binding domain, GABA-A receptor, ion channel, neurotransmitter-gated ion channel ligand binding domain
