TTRAP - TRAF and TNF receptor associated protein
Entrez Gene Name: TRAF and TNF receptor associated protein
Entrez GeneID: Human(51567)
, Mouse(56196), Rat(498749)
, Mouse(56196), Rat(498749) Synonyms: AD022, D13Ertd656e, dJ30M3.3, EAP2, MGC111021, MGC124734, MGC9099, RP1-30M3.3, TTRAP
Gene Summary
- Human (51567): This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Literature References
- 12743594Pei H, Yordy JS, Leng Q, Zhao Q, Watson DK, Li R. EAPII interacts with ETS1 and modulates its transcriptional function.Oncogene 2003 May 8;22(18):2699-709
- 10764746Pype S, Declercq W, Ibrahimi A, Michiels C, Van Rietschoten JG, Dewulf N, de Boer M, Vandenabeele P, Huylebroeck D, Remacle JE. TTRAP, a novel protein that associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor-associated factors (TRAFs), and that inhibits nuclear factor-kappa B activation.J Biol Chem 2000 06 16;275(24):18586-93
- 14988562Odom DT, Zizlsperger N, Gordon DB, Bell GW, Rinaldi NJ, Murray HL, Volkert TL, Schreiber J, Rolfe PA, Gifford DK, Fraenkel E, Bell GI, Young RA. Control of pancreas and liver gene expression by HNF transcription factors.Science 2004 02 27;303(5662):1378-81 View 141 categorized literature findings and their references in IPA
Molecular Functions
endonuclease activity, phosphoric diester hydrolase activity, protein binding, receptor activity, transcription corepressor activity
Protein Domains
endonuclease, Phosphoric diester hydrolase, protein binding, transcription co-repressor, transcription regulator
