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CDT1 - chromatin licensing and DNA replication factor 1
Entrez Gene Name: chromatin licensing and DNA replication factor 1
Entrez GeneID: Human(81620), Mouse(67177), Rat(292071)
Synonyms: 2610318F11Rik, AW545653, C76791, CDT1, DUP, RIS2

Gene Summary

No Data Available
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras

Cell Regulation

Regulates:
  • CDT1
  • Mcm4
  • NBN
View all 11 in IPA
Regulated by:
  • CDT1
  • GMNN
  • SKP2
View all 37 in IPA
Binds:
  • GMNN
  • SKP2
  • PCNA
View all 26 in IPA
Role in cell:
  • phosphorylation in
  • degradation in
  • re-replication in
View all 7 in IPA
Disease:
  • No Data Available

Biological Process

cell cycle, DNA replication, DNA replication checkpoint, regulation of DNA replication initiation, regulation of S phase of mitotic cell cycle

Cellular Components

nucleoplasm, nucleus

Literature References

  • 15257290Ballabeni A, Melixetian M, Zamponi R, Masiero L, Marinoni F, Helin K. Human Geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis.EMBO J 2004 Aug 04;23(15):3122-32
  • 15232106Ramachandran N, Hainsworth E, Bhullar B, Eisenstein S, Rosen B, Lau AY, Walter JC, LaBaer J. Self-assembling protein microarrays.Science 2004 07 2;305(5680):86-90
  • 19054765Ballabeni A, Zamponi R, Caprara G, Melixetian M, Bossi S, Masiero L, Helin K. Human CDT1 Associates with CDC7 and Recruits CDC45 to Chromatin during S Phase.J Biol Chem 2009 Jan 30;284(5):3028-36
    • View 512 categorized literature findings and their references in IPA

Molecular Functions

DNA binding, protein binding

Pathways

No Data Available

Protein Domains

cyclin-binding domain, DNA binding, protein binding

Subcellular Locations

chromatin fraction, insoluble fractions, nuclear fraction, nucleoli, nucleus, soluble fraction

IPA Extras