CYP1A2 - cytochrome P450, family 1, subfamily A, polypeptide 2
Entrez Gene Name: cytochrome P450, family 1, subfamily A, polypeptide 2
Entrez GeneID: Human(1544)
, Mouse(13077), Rat(24297)
, Mouse(13077), Rat(24297) Synonyms: CP12, CYP1A2, CYPD45, CYPIA2, P-450d, P-450isf-g, P3-450, p450 1A2, P450 IA2, P450(PA), P450-3, P450-P3, RATCYPD45
Gene Summary
- Human (1544): This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq]
- Rat (24297): a monooxygenase that may play a role in xenobiotic metabolism [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cellular aromatic compound metabolic process, cellular respiration, dibenzo-p-dioxin metabolic process, drug metabolic process, hydrogen peroxide biosynthetic process, lung development, oxidation reduction, porphyrin metabolic process, post-embryonic development, regulation of gene expression, response to drug, response to estradiol stimulus, response to lipopolysaccharide, response to organic cyclic substance, response to organic substance, response to stress, toxin metabolic process, xenobiotic metabolic process
Literature References
- 11264468Lin JH, Lu AY. Interindividual variability in inhibition and induction of cytochrome P450 enzymes.Annu Rev Pharmacol Toxicol 2001;41:535-67
- 15523539Vrzal R, Ulrichova J, Dvorak Z. Aromatic hydrocarbon receptor status in the metabolism of xenobiotics under normal and pathophysiological conditions.Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2004 07 1;148(1):3-10
- 14570767Lu P, Schrag ML, Slaughter DE, Raab CE, Shou M, Rodrigues AD. Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor.Drug Metab Dispos 2003 11 1;31(11):1352-60 View 1077 categorized literature findings and their references in IPA
Molecular Functions
aromatase activity, demethylase activity, electron carrier activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, oxygen binding
Subcellular Locations
cell surface, cytoplasm, endoplasmic reticulum membrane, microsomal fraction, microsome, plasma membrane
