HMOX1 - heme oxygenase (decycling) 1
Entrez Gene Name: heme oxygenase (decycling) 1
Entrez GeneID: Human(3162)
, Mouse(15368), Rat(24451)
, Mouse(15368), Rat(24451) Synonyms: bK286B10, D8Wsu38e, HEME OXYGENASE, HEME OXYGENASE (DECYCLIZING) 1, HEME OXYGENASE-1, Hemox, Heox, HEOXG, Hmox, HMOX1, HO-1, HSP32
Gene Summary
- Human (3162): Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. [provided by RefSeq]
- Rat (24451): catalyzes the oxidative cleavage of heme to biliverdin [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
angiogenesis, cell death, cellular response to nutrient, DNA damage response, signal transduction resulting in induction of apoptosis, endothelial cell proliferation, erythrocyte homeostasis, excretion, healing during inflammatory response, heme catabolic process, heme oxidation, intracellular signaling cascade, iron ion homeostasis, low-density lipoprotein particle clearance, negative regulation of cell proliferation, negative regulation of DNA binding, negative regulation of leukocyte migration, negative regulation of mast cell cytokine production, negative regulation of mast cell degranulation, negative regulation of transcription factor activity, oxidation reduction, phospholipid metabolic process, positive regulation of anti-apoptosis, positive regulation of chemokine biosynthetic process, positive regulation of I-kappaB kinase/NF-kappaB cascade, positive regulation of vasodilation, protein kinase cascade, regulation of angiogenesis, regulation of blood pressure, regulation of transcription from RNA polymerase II promoter in response to oxidative stress, response to estrogen stimulus, response to hydrogen peroxide, response to hypoxia, response to nicotine, response to oxidative stress, response to stimulus, small GTPase mediated signal transduction, smooth muscle hyperplasia
Cellular Components
caveola, cytosol, endoplasmic reticulum, extracellular space, membrane fraction, microsome, nucleolus, nucleus, plasma membrane
Literature References
- 18025230Seldon MP, Silva G, Pejanovic N, Larsen R, Gregoire IP, Filipe J, Anrather J, Soares MP. Heme Oxygenase-1 Inhibits the Expression of Adhesion Molecules Associated with Endothelial Cell Activation via Inhibition of NF-{kappa}B RelA Phosphorylation at Serine 276.J Immunol 2007 Dec 01;179(11):7840-51
- 17567933Traylor A, Hock T, Hill-Kapturczak N. Specificity protein 1 and Smad-dependent regulation of human heme oxygenase-1 gene by transforming growth factor-beta1 in renal epithelial cells.Am J Physiol Renal Physiol 2007 Sep 01;293(3):F885-94
- 17420286Kondo R, Gleixner KV, Mayerhofer M, Vales A, Gruze A, Samorapoompichit P, Greish K, Krauth MT, Aichberger KJ, Pickl WF, Esterbauer H, Sillaber C, Maeda H, Valent P. Identification of heat shock protein 32 (Hsp32) as a novel survival factor and therapeutic target in neoplastic mast cells.Blood 2007 Jul 15;110(2):661-9 View 1489 categorized literature findings and their references in IPA
Molecular Functions
enzyme binding, heme binding, heme oxygenase (decyclizing) activity, iron ion binding, metal ion binding, oxidoreductase activity, phospholipase D activity, protein binding, signal transducer activity
- NRF2-mediated Oxidative Stress Response
- Acute Phase Response Signaling
- IL-8 Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- IL-10 Signaling
- Inositol Metabolism
- Endothelin-1 Signaling
- Phospholipid Degradation
- Xenobiotic Metabolism Signaling
- Glycerophospholipid Metabolism
- mTOR Signaling
- Pancreatic Adenocarcinoma Signaling
Protein Domains
enzyme, enzyme binding, heme binding, Heme oxygenase (decyclizing), Oxidoreductase, Phospholipase D, protein binding, signal transducer
