CHRNB4 - cholinergic receptor, nicotinic, beta 4
Entrez Gene Name: cholinergic receptor, nicotinic, beta 4
Entrez GeneID: Human(1143)
, Mouse(108015), Rat(25103)
, Mouse(108015), Rat(25103) Synonyms: Acrb-4, CHRNB4, NACHR BETA4
Gene Summary
- Rat (25103): may act as a subunit of a neuronal nicotinic acetylcholine receptor [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
behavioral response to nicotine, ion transport, locomotory behavior, protein heterooligomerization, regulation of action potential, regulation of membrane potential, regulation of neurotransmitter secretion, regulation of smooth muscle contraction, response to nicotine, signal transduction, smooth muscle contraction, synaptic transmission involved in micturition, synaptic transmission, cholinergic, transport
Cellular Components
cell junction, integral to membrane, membrane, membrane fraction, nicotinic acetylcholine-gated receptor-channel complex, plasma membrane, postsynaptic membrane, synapse, synaptosome
Literature References
- 17065235Young GT, Broad LM, Zwart R, Astles PC, Bodkin M, Sher E, Millar NS. Species Selectivity of a Nicotinic Acetylcholine Receptor Agonist Is Conferred by Two Adjacent Extracellular beta4 Amino Acids that Are Implicated in the Coupling of Binding to Channel Gating.Mol Pharmacol 2007 Feb 01;71(2):389-97
- 16738207Broad LM, Zwart R, Pearson KH, Lee M, Wallace L, McPhie GI, Emkey R, Hollinshead SP, Dell CP, Baker SR, Sher E. Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators.J Pharmacol Exp Ther 2006 Sep 01;318(3):1108-17
- 15016836Xiao Y, Kellar KJ. The comparative pharmacology and up-regulation of rat neuronal nicotinic receptor subtype binding sites stably expressed in transfected Mammalian cells.J Pharmacol Exp Ther 2004 Jul 01;310(1):98-107 View 462 categorized literature findings and their references in IPA
Molecular Functions
acetylcholine binding, acetylcholine receptor activity, drug binding, extracellular ligand-gated ion channel activity, ion channel activity, neurotransmitter receptor activity, nicotinic acetylcholine-activated cation-selective channel activity, receptor activity
Protein Domains
acetylcholine receptor, extracellular ligand binding domain, extracellular ligand-gated ion channel, GABA-A receptor, ion channel, neurotransmitter-gated ion channel ligand binding domain, nicotinic acetylcholine-activated cation-selective channel, transmembrane receptor
