CD82 - CD82 molecule
Entrez Gene Name: CD82 molecule
Entrez GeneID: Human(3732)
, Mouse(12521), Rat(83628)
, Mouse(12521), Rat(83628) Synonyms: 4F9, AA682076, AL023070, C33, C33 antigen, CD82, GR15, IA4, KAI1, Kangai1, R2, SAR2, ST6, TSPAN27
Gene Summary
- Human (3732): This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq]
- Rat (83628): a metastasis suppressor gene; loss of expression is associated with increased metastatic potential of prostate cancer cells [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Literature References
- 12150997Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG. Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein.Cell 2002 Jul 12;110(1):55-67
- 17215249Todeschini AR, Dos Santos JN, Handa K, Hakomori SI. Ganglioside GM2-Tetraspanin CD82 Complex Inhibits Met and Its Cross-talk with Integrins, Providing a Basis for Control of Cell Motility through Glycosynapse.J Biol Chem 2007 Mar 16;282(11):8123-33
- 17210782Tohami T, Drucker L, Shapiro H, Radnay J, Lishner M. Overexpression of tetraspanins affects multiple myeloma cell survival and invasive potential.FASEB J 2007 Mar 01;21(3):691-9 View 479 categorized literature findings and their references in IPA
Subcellular Locations
cell periphery, cell surface, cellular membrane, cytoplasm, cytoplasmic vesicles, endolysosomal tubule, inner membrane, intercellular junctions, membrane rafts, MHC class II compartments, perinuclear vesicles, plasma membrane
