CHRNA7 - cholinergic receptor, nicotinic, alpha 7
Entrez Gene Name: cholinergic receptor, nicotinic, alpha 7
Entrez GeneID: Human(1139)
, Mouse(11441), Rat(25302)
, Mouse(11441), Rat(25302) Synonyms: ACHR ALPHA 7, AChR alpha 7 Receptor, Acra7, ALPHA-7NACHR, ALPHA7, ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR, Alpha7 nicr, BTX, CHRNA7, CHRNA7-2, NACHR alpha7, NACHRA7, NARAD
Gene Summary
- Human (1139): The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. [provided by RefSeq]
- Rat (25302): subunit of nicotinic acetylcholline receptor; may mediate nicotine induced increase in tyrosine hydroxylase expression; may play a role in neuroprotection [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of MAPK activity, associative learning, B cell activation, behavioral response to ethanol, behavioral response to nicotine, calcium ion transport, cellular calcium ion homeostasis, cognition, dopamine biosynthetic process, endocytosis, generation of ovulation cycle rhythm, ion transport, memory, negative regulation of inflammatory response, negative regulation of interleukin-1 beta production, negative regulation of interleukin-6 production, negative regulation of tumor necrosis factor production, ovulation cycle, positive regulation of angiogenesis, positive regulation of cell proliferation, positive regulation of heart rate in baroreceptor response to decreased systemic arterial blood pressure, regulation of action potential in neuron, regulation of inflammatory response, regulation of membrane potential, regulation of norepinephrine secretion, regulation of synaptic transmission, dopaminergic, response to chemical stimulus, response to ethanol, response to food, response to hypoxia, response to nicotine, signal transduction, sperm motility, synaptic transmission, cholinergic, T cell activation, transport
Cellular Components
apical plasma membrane, asymmetric synapse, axon, cell junction, cell soma, cytoplasm, dendrite, dendritic shaft, dendritic spine, external side of plasma membrane, growth cone, integral to membrane, membrane, membrane fraction, membrane raft, nicotinic acetylcholine-gated receptor-channel complex, plasma membrane, postsynaptic density, postsynaptic membrane, presynaptic membrane, synapse
Literature References
- 17329232Carter CJ. EIF2B and Oligodendrocyte Survival: Where Nature and Nurture Meet in Bipolar Disorder and Schizophrenia?Schizophr Bull 2007 Nov 01;33(6):1343-53
- 17709503Razani-Boroujerdi S, Boyd RT, Davila-García MI, Nandi JS, Mishra NC, Singh SP, Pena-Philippides JC, Langley R, Sopori ML. T cells express alpha7-nicotinic acetylcholine receptor subunits that require a functional TCR and leukocyte-specific protein tyrosine kinase for nicotine-induced Ca2+ response.J Immunol 2007 09 1;179(5):2889-98
- 17507554Farías GG, Vallés AS, Colombres M, Godoy JA, Toledo EM, Lukas RJ, Barrantes FJ, Inestrosa NC. Wnt-7a induces presynaptic colocalization of alpha 7-nicotinic acetylcholine receptors and adenomatous polyposis coli in hippocampal neurons.J Neurosci 2007 May 16;27(20):5313-25 View 672 categorized literature findings and their references in IPA
Molecular Functions
acetylcholine binding, acetylcholine receptor activity, adenylate cyclase binding, beta-amyloid binding, chloride channel regulator activity, drug binding, extracellular ligand-gated ion channel activity, ion channel activity, neurotransmitter receptor activity, nicotinic acetylcholine-activated cation-selective channel activity, protein binding, protein homodimerization activity, protein kinase binding, receptor activity, toxin binding
Protein Domains
acetylcholine binding, acetylcholine receptor, adenylate cyclase binding, beta-amyloid binding, carboxy terminal domain, chloride channel regulator, cytoplasmic loop, drug binding, extracellular ligand binding domain, intracellular domain, N-terminal domain, neurotransmitter-gated ion channel ligand binding domain, nicotinic acetylcholine-activated cation-selective channel, protein binding, protein homodimerization, protein kinase binding, toxin binding, transmembrane domain, transmembrane receptor
Subcellular Locations
cell body, cell surface, cellular membrane, cytoplasm, membrane fraction, plasma membrane, synaptosomes
