CENPA - centromere protein A
Entrez Gene Name: centromere protein A
Entrez GeneID: Human(1058)
, Mouse(12615), Rat(298850)
, Mouse(12615), Rat(298850) Synonyms: CENPA, CENTROMERE PROTEIN A, RGD1563607
Gene Summary
- Human (1058): Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Cellular Components
chromosome, chromosome, centromeric region, condensed chromosome kinetochore, inner kinetochore of condensed chromosome, nucleosome, nucleus
Literature References
- 12515822Goshima G, Kiyomitsu T, Yoda K, Yanagida M. Human centromere chromatin protein hMis12, essential for equal segregation, is independent of CENP-A loading pathway.J Cell Biol 2003 Jan 6;160(1):25-39
- 16314512Wang IC, Chen YJ, Hughes D, Petrovic V, Major ML, Park HJ, Tan Y, Ackerson T, Costa RH. Forkhead Box M1 Regulates the Transcriptional Network of Genes Essential for Mitotic Progression and Genes Encoding the SCF (Skp2-Cks1) Ubiquitin Ligase.Mol Cell Biol 2005 Dec 01;25(24):10875-94
- 15369671Hayashi T, Fujita Y, Iwasaki O, Adachi Y, Takahashi K, Yanagida M. Mis16 and Mis18 Are Required for CENP-A Loading and Histone Deacetylation at Centromeres.Cell 2004 Sep 17;118(6):715-29 View 130 categorized literature findings and their references in IPA
