CSNK2A1 - casein kinase 2, alpha 1 polypeptide
Entrez Gene Name: casein kinase 2, alpha 1 polypeptide
Entrez GeneID: Human(1457)
, Mouse(12995), Rat(116549)
, Mouse(12995), Rat(116549) Synonyms: Ck II Alpha Subunit, CK1 ALPHA2, CK2 ALPHA, Ck2 alpha1, CK2A1, CKII, CKII alpha, CSNK2A1, Csnk2a1-rs4, MGC102141
Gene Summary
- Human (1457): Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene. [provided by RefSeq]
- Rat (116549): alpha subunit of casein kinase II, a protein serine/threonine kinase that may play a role in regulation of cell growth and proliferation [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
protein amino acid autophosphorylation, protein amino acid phosphorylation, regulation of cell growth, regulation of cell proliferation, signal transduction, Wnt receptor signaling pathway
Literature References
- 12145206Skjerpen CS, Nilsen T, Wesche J, Olsnes S. Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity.EMBO J 2002 Aug 1;21(15):4058-69
- 16977309Scott GK, Fei H, Thomas L, Medigeshi GR, Thomas G. A PACS-1, GGA3 and CK2 complex regulates CI-MPR trafficking.EMBO J 2006 Oct 04;25(19):4423-35
- 15502875John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets.PLoS Biol 2004 11 1;2(11):e363 View 1601 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, beta-catenin binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein N-terminus binding, protein phosphatase regulator activity, protein serine/threonine kinase activity, transferase activity
Protein Domains
beta-catenin binding, kinase, protein binding, Protein kinase, protein N-terminus binding, protein phosphatase regulator, protein serine/threonine kinase
