LAMA3 - laminin, alpha 3
Entrez Gene Name: laminin, alpha 3
Entrez GeneID: Human(3909)
, Mouse(16774), Rat(307582)
, Mouse(16774), Rat(307582) Synonyms: a 3B, BM600, E170, LAMA3, lama3a, Lama3B, LAMININ 5 ALPHA 3, LAMININ 5 ALPHA3-200, LAMININ ALPHA 3, LAMNA, LOCS
Gene Summary
- Human (3909): Laminins are basement membrane components thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. The protein encoded by this gene is the alpha-3 subunit of laminin 5, which is a complex glycoprotein composed of three subunits (alpha, beta, and gamma). Laminin 5 is thought to be involved in cell adhesion, signal transduction and differentiation of keratinocytes. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq]
- Rat (307582): alpha chain of laminin 5 which is a structural component of hemidesmosomes that may be involved in assembly and integrity of hemidesmosomes [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cell adhesion, cell-cell adhesion, epidermis development, hemidesmosome assembly, regulation of cell adhesion, regulation of cell migration, regulation of embryonic development
Cellular Components
basement membrane, cell-cell adherens junction, extracellular matrix, extracellular region, extracellular space, hemidesmosome, laminin-1 complex, laminin-3 complex, proteinaceous extracellular matrix
Literature References
- 10700174Ross DT, Scherf U, Eisen MB, Perou CM, Rees C, Spellman P, Iyer V, Jeffrey SS, Van de Rijn M, Waltham M, Pergamenschikov A, Lee JC, Lashkari D, Shalon D, Myers TG, Weinstein JN, Botstein D, Brown PO. Systematic variation in gene expression patterns in human cancer cell lines [see comments]Nat Genet 2000 Mar;24(3):227-35
- 16608848Yan HH, Cheng CY. Laminin alpha 3 forms a complex with beta3 and gamma3 chains that serves as the ligand for alpha 6beta1-integrin at the apical ectoplasmic specialization in adult rat testes.J Biol Chem 2006 Jun 23;281(25):17286-303
- 15574877Klees RF, Salasznyk RM, Kingsley K, Williams WA, Boskey A, Plopper GE. Laminin-5 Induces Osteogenic Gene Expression in Human Mesenchymal Stem Cells through an ERK-dependent Pathway.Mol Biol Cell 2005 Feb 01;16(2):881-90 View 533 categorized literature findings and their references in IPA
Protein Domains
globular domain, heparin binding domain, laminin B domain, laminin EGF-like domain, Laminin-G repeat, Laminin-type G domain 4 module, protein binding
Subcellular Locations
apical ectoplasmic specialization, basal lamina, basement membrane, extracellular space
