MAPRE1 - microtubule-associated protein, RP/EB family, member 1
Entrez Gene Name: microtubule-associated protein, RP/EB family, member 1
Entrez GeneID: Human(22919)
, Mouse(13589), Rat(114764)
, Mouse(13589), Rat(114764) Synonyms: 5530600P05RIK, AI462499, AI504412, AW260097, BIM1p, D2Ertd459e, EB1, MAPRE1, MGC117374, MGC129946
Gene Summary
- Human (22919): The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq]
- Rat (114764): expressed specifically at growing microtubule distal tips [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cell cycle, cell division, cell proliferation, mitosis, negative regulation of microtubule polymerization
Cellular Components
cell projection, cell projection membrane, centrosome, cortical microtubule cytoskeleton, cytoplasm, cytoplasmic microtubule, cytoskeleton, Golgi apparatus, microtubule, spindle
Literature References
- 15502875John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets.PLoS Biol 2004 11 1;2(11):e363
- 16148041Komarova Y, Lansbergen G, Galjart N, Grosveld F, Borisy GG, Akhmanova A. EB1 and EB3 Control CLIP Dissociation from the Ends of Growing Microtubules.Mol Biol Cell 2005 Nov 01;16(11):5334-45
- 16007168Wang Y, Zhou X, Zhu H, Liu S, Zhou C, Zhang G, Xue L, Lu N, Quan L, Bai J, Zhan Q, Xu N. Overexpression of EB1 in human esophageal squamous cell carcinoma (ESCC) may promote cellular growth by activating beta-catenin/TCF pathway.Oncogene 2005 Oct 06;24(44):6637-45 View 447 categorized literature findings and their references in IPA
Molecular Functions
microtubule binding, microtubule plus-end binding, protein binding, protein C-terminus binding
Protein Domains
acidic domain, calponin homology domain, carboxy terminal domain, coiled-coil domain, leucine zipper domain, N-terminal domain, protein binding, protein C-terminus binding
Subcellular Locations
centriole, centrosome, cytoplasm, cytosolic fraction, filamentous network, microtubule tips, microtubules, mitotic spindle, plasma membrane, plus end of microtubule, pseudopodia
