HTR6 - 5-hydroxytryptamine (serotonin) receptor 6
Entrez Gene Name: 5-hydroxytryptamine (serotonin) receptor 6
Entrez GeneID: Human(3362)
, Mouse(15565), Rat(64354)
, Mouse(15565), Rat(64354) Synonyms: 5-HT6, 5-HT6R, HTR6, MGC144682, MGC144683
Gene Summary
- Rat (64354): G-protein coupled receptor for serotonin [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Role in cell:
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Biological Process
G-protein coupled receptor protein signaling pathway, G-protein signaling, coupled to cyclic nucleotide second messenger, signal transduction, synaptic transmission
Literature References
- 17189269Yun HM, Kim S, Kim HJ, Kostenis E, Kim JI, Seong JY, Baik JH, Rhim H. The novel cellular mechanism of human 5-HT6 receptor through an interaction with Fyn.J Biol Chem 2007 Feb 23;282(8):5496-505
- 14645659Hirst WD, Abrahamsen B, Blaney FE, Calver AR, Aloj L, Price GW, Medhurst AD. Differences in the central nervous system distribution and pharmacology of the mouse 5-hydroxytryptamine-6 receptor compared with rat and human receptors investigated by radioligand binding, site-directed mutagenesis, and molecular modeling.Mol Pharmacol 2003 Dec 01;64(6):1295-308
- 12975483Lindner MD, Hodges DB, Hogan JB, Orie AF, Corsa JA, Barten DM, Polson C, Robertson BJ, Guss VL, Gillman KW, Starrett JE, Gribkoff VK. An assessment of the effects of serotonin 6 (5-HT6) receptor antagonists in rodent models of learning.J Pharmacol Exp Ther 2003 Nov 01;307(2):682-91 View 280 categorized literature findings and their references in IPA
Molecular Functions
G-protein coupled receptor activity, histamine receptor activity, protein binding, receptor activity, serotonin receptor activity, signal transducer activity
Protein Domains
carboxy terminal domain, G-protein coupled receptor, histamine receptor, protein binding, serotonin receptor
Subcellular Locations
cell body, cellular membrane, intracellular membranes, membrane fraction, plasma membrane
