CASP7 - caspase 7, apoptosis-related cysteine peptidase
Entrez Gene Name: caspase 7, apoptosis-related cysteine peptidase
Entrez GeneID: Human(840)
, Mouse(12369), Rat(64026)
, Mouse(12369), Rat(64026) Synonyms: AI314680, CASP7, CASPASE7, CMH-1, ICE-IAP3, ICE-LAP3, Lice2 cysteine protease, mCASP-7, MCH3
Gene Summary
- Human (840): This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of this caspase is cleaved by caspase 3 and 10. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms. [provided by RefSeq]
- Rat (64026): member of the cysteine-aspartic acid protease (caspase) family that mediates terminal phase of apoptosis [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
apoptosis, heart development, induction of apoptosis, proteolysis, regulation of apoptosis, release of cytochrome c from mitochondria, response to UV
Cellular Components
cytoplasm, cytosol, endoplasmic reticulum membrane, mitochondrial membrane, soluble fraction
Literature References
- 14556717Yuan J, Lipinski M, Degterev A. Diversity in the mechanisms of neuronal cell death.Neuron 2003 Oct 09;40(2):401-13
- 11257230Chai J, Shiozaki E, Srinivasula SM, Wu Q, Dataa P, Alnemri ES, Shi Y. Structural Basis of Caspase-7 Inhibition by XIAP.Cell 2001 Mar 9;104(5):769-780
- 10872455Earnshaw WC, Martins LM, Kaufmann SH. Mammalian caspases: structure, activation, substrates, and functions during apoptosis.Annu Rev Biochem 1999;68:383-424 View 2424 categorized literature findings and their references in IPA
Molecular Functions
cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, peptidase activity, protein binding
- Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells
- Amyotrophic Lateral Sclerosis Signaling
- Endoplasmic Reticulum Stress Pathway
- Endothelin-1 Signaling
- Sphingosine-1-phosphate Signaling
- Huntington's Disease Signaling
- Molecular Mechanisms of Cancer
- Lysine Degradation
- Apoptosis Signaling
- Death Receptor Signaling
Subcellular Locations
cytoplasm, cytoplasmic fraction, cytosol, cytosolic fraction, membrane rafts, mitochondrial fraction
