CUL4A - cullin 4A
Entrez Gene Name: cullin 4A
Entrez GeneID: Human(8451)
, Mouse(99375), Rat(361181)
, Mouse(99375), Rat(361181) Synonyms: 2810470J21Rik, AW495282, CUL4, CUL4A, Cullin 4a, MGC36573, RGD1563853
Gene Summary
No Data Available
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
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Biological Process
cell cycle arrest, DNA repair, G1/S transition of mitotic cell cycle, induction of apoptosis by intracellular signals, modification-dependent protein catabolic process, negative regulation of cell proliferation, response to DNA damage stimulus, ubiquitin-dependent protein catabolic process
Literature References
- 17079684He YJ, McCall CM, Hu J, Zeng Y, Xiong Y. DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases.Genes Dev 2006 11 1;20(21):2949-54
- 14739464Wertz IE, O'Rourke KM, Zhang Z, Dornan D, Arnott D, Deshaies RJ, Dixit VM. Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase.Science 2004 Feb 27;303(5662):1371-4
- 14609952Zhang Y, Morrone G, Zhang J, Chen X, Lu X, Ma L, Moore M, Zhou P. CUL-4A stimulates ubiquitylation and degradation of the HOXA9 homeodomain protein.EMBO J 2003 11 17;22(22):6057-67 View 280 categorized literature findings and their references in IPA
