CASP8 - caspase 8, apoptosis-related cysteine peptidase
Entrez Gene Name: caspase 8, apoptosis-related cysteine peptidase
Entrez GeneID: Human(841)
, Mouse(12370), Rat(64044)
, Mouse(12370), Rat(64044) Synonyms: ALPS2B, CAP4, CASP8, CASPASE-8, FLICE, FLJ17672, MACH, MCH5, MGC78473, PROCASP8
Gene Summary
- Human (841): This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq]
- Rat (64044): member of the cysteine-aspartic acid protease (caspase) familythat mediates the terminal stage of apoptosis; involved in apoptosis induced by Fas and other stimuli [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of pro-apoptotic gene products, angiogenesis, apoptosis, heart development, induction of apoptosis by extracellular signals, macrophage differentiation, neural tube formation, positive regulation of I-kappaB kinase/NF-kappaB cascade, protein heterooligomerization, proteolysis, proteolysis involved in cellular protein catabolic process, regulation of apoptosis, response to tumor necrosis factor
Cellular Components
centrosome, cytoplasm, cytoskeleton, cytosol, death-inducing signaling complex, membrane raft, mitochondrion, Noc1p-Noc2p complex, nucleus, protein complex
Literature References
- 16169070Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE. A human protein-protein interaction network: a resource for annotating the proteome.Cell 2005 Sep 23;122(6):957-68
- 16157684Salmena L, Hakem R. Caspase-8 deficiency in T cells leads to a lethal lymphoinfiltrative immune disorder.J Exp Med 2005 Sep 19;202(6):727-32
- 14556717Yuan J, Lipinski M, Degterev A. Diversity in the mechanisms of neuronal cell death.Neuron 2003 Oct 09;40(2):401-13 View 5524 categorized literature findings and their references in IPA
Molecular Functions
cysteine-type endopeptidase activity, cysteine-type peptidase activity, hydrolase activity, identical protein binding, peptidase activity, protein binding
- Apoptosis Signaling
- Huntington's Disease Signaling
- Role of RIG1-like Receptors in Antiviral Innate Immunity
- Type I Diabetes Mellitus Signaling
- Induction of Apoptosis by HIV1
- Retinoic acid Mediated Apoptosis Signaling
- Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells
- Sphingosine-1-phosphate Signaling
- Molecular Mechanisms of Cancer
- Role of PKR in Interferon Induction and Antiviral Response
- Death Receptor Signaling
- CD27 Signaling in Lymphocytes
- Mitochondrial Dysfunction
- Myc Mediated Apoptosis Signaling
- Endothelin-1 Signaling
- Lysine Degradation
Protein Domains
caspase domain, catalytic domain, Cysteine endopeptidase, death effector domain, Death effector domain-interacting domain, peptidase, pro domain, protein binding, protein self binding
Subcellular Locations
cellular membrane, cytoplasm, cytoplasmic fraction, cytosol, cytosolic fraction, membrane rafts, mitochondria, mitochondrial inner membrane, mitochondrial intermembrane space, mitochondrial matrix, nucleus, plasma membrane
