CALCA - calcitonin-related polypeptide alpha
Entrez Gene Name: calcitonin-related polypeptide alpha
Entrez GeneID: Human(796)
Synonyms: CA, Cal1, CAL6, CALC, CALC1, CALCA, CGRP, CGRP-1, CGRP-I, CT, CTN, KC, MGC126648, RATCAL6
Gene Summary
- Human (796): Calcitonin is a peptide hormone synthesized by the parafollicular cells of the thyroid. It causes reduction in serum calcium, an effect opposite to that of parathyroid hormone (PTH; MIM 168450).[supplied by OMIM]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of adenylate cyclase activity by G-protein signaling pathway, activation of protein kinase activity, cell-cell signaling, cytosolic calcium ion homeostasis, detection of temperature stimulus involved in sensory perception of pain, elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating), embryo implantation, endothelial cell migration, endothelial cell proliferation, feeding behavior, leukocyte adhesion, negative regulation of blood pressure, negative regulation of bone resorption, negative regulation of calcium ion transport into cytosol, negative regulation of neurological system process, negative regulation of ossification, negative regulation of osteoclast differentiation, negative regulation of smooth muscle contraction, negative regulation of transcription, neurological system process involved in regulation of systemic arterial blood pressure, neuropeptide signaling pathway, positive regulation of adenylate cyclase activity, positive regulation of cell adhesion, positive regulation of interleukin-1 alpha production, positive regulation of interleukin-8 production, positive regulation of macrophage differentiation, positive regulation of ossification, positive regulation of vasodilation, regulation of heart rate, regulation of inflammatory response, response to heat, response to pain, vasculature development, vasodilation of artery during baroreceptor response to increased systemic arterial blood pressure
Cellular Components
axon, cell soma, cytoplasm, extracellular region, extracellular space, intracellular, nucleus, terminal button
Literature References
- 17579082Harzenetter MD, Novotny AR, Gais P, Molina CA, Altmayr F, Holzmann B. Negative Regulation of TLR Responses by the Neuropeptide CGRP Is Mediated by the Transcriptional Repressor ICER.J Immunol 2007 Jul 01;179(1):607-15
- 17194737Tavares E, Maldonado R, Miñano FJ. N-procalcitonin: central effects on feeding and energy homeostasis in rats.Endocrinology 2007 Apr 01;148(4):1891-901
- 16912219Udawela M, Christopoulos G, Morfis M, Christopoulos A, Ye S, Tilakaratne N, Sexton PM. A critical role for the short intracellular C terminus in receptor activity-modifying protein function.Mol Pharmacol 2006 Nov 01;70(5):1750-60 View 884 categorized literature findings and their references in IPA
Subcellular Locations
axons, C fiber, cell body, cell surface, dense-core vesicles, extracellular space, granules, plasma membrane
