ESR2 - estrogen receptor 2 (ER beta)
Entrez Gene Name: estrogen receptor 2 (ER beta)
Entrez GeneID: Human(2100)
, Mouse(13983), Rat(25149)
, Mouse(13983), Rat(25149) Synonyms: BETA ESTROGEN RECEPTOR, ER-BETA, ER b , ERB, ERB2, ESR-BETA, ESR2, ESRB, ESTRB, ESTROGEN RECEPTOR BETA, NR3A2
Gene Summary
- Human (2100): This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq]
- Rat (25149): binds estrogen and mediates transcriptional activation [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
behavioral fear response, brain development, cell-cell signaling, estrogen receptor signaling pathway, learning or memory, negative regulation of behavior, negative regulation of cell growth, negative regulation of cell proliferation, negative regulation of epithelial cell proliferation, neuron migration, neuroprotection, positive regulation of gene-specific transcription, positive regulation of survival gene product expression, positive regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, response to testosterone stimulus, signal transduction, transcription
Literature References
- 12374744Wang RA, Mazumdar A, Vadlamudi RK, Kumar R. P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium.EMBO J 2002 Oct 15;21(20):5437-47
- 11964479Tran H, Brunet A, Grenier JM, Datta SR, Fornace AJ, DiStefano PS, Chiang LW, Greenberg ME. DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein.Science 2002 Apr 19;296(5567):530-4
- 9582273van Agthoven T, van Agthoven TL, Dekker A, van der Spek PJ, Vreede L, Dorssers LC. Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells.EMBO J 1998 May 15;17(10):2799-808 View 6208 categorized literature findings and their references in IPA
Molecular Functions
DNA binding, estrogen receptor activity, hormone binding, ligand-dependent nuclear receptor activity, lipid binding, metal ion binding, protein binding, receptor activity, receptor antagonist activity, sequence-specific DNA binding, steroid binding, steroid hormone receptor activity, transcription coactivator activity, transcription factor activity, transcription regulator activity, zinc ion binding
Protein Domains
A/B region, AF-1 domain, AF-2 transcription activation domain, C4 type zinc finger domain, carboxy terminal domain, DNA binding, DNA binding domain, E domain, estrogen receptor, Estrogen receptor A/B domain, hormone binding, hormone binding domain, ligand-binding domain, ligand-dependent nuclear receptor, N-terminal domain, protein binding, steroid binding, transcription co-activator, transcription factor, transcription regulator
Subcellular Locations
axons, caveolae, cell body, cytoplasm, cytosol, cytosolic fraction, dendrites, inner nuclear membrane, membrane processes, microsome, mitochondria, mitochondrial fraction, nerve ending, neurites, nuclear fraction, nuclear membrane fraction, nucleus, perinuclear region, plasma membrane, plasma membrane fraction, soluble fraction
