PRKCA - protein kinase C, alpha
Entrez Gene Name: protein kinase C, alpha
Entrez GeneID: Human(5578)
, Mouse(18750), Rat(24680)
, Mouse(18750), Rat(24680) Synonyms: AAG6, AI875142, LOC146784, MGC129900, MGC129901, PKC ALPHA, PKCA, PKRCA, PRKACA, PRKCA
Gene Summary
- Human (5578): Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq]
- Rat (24680): displays Ca+2 dependent protein kinase activity [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
aging, cellular calcium ion homeostasis, central nervous system neuron axonogenesis, chondrocyte differentiation, establishment of protein localization, inactivation of MAPK activity, induction of apoptosis by extracellular signals, induction of apoptosis by intracellular signals, induction of positive chemotaxis, intracellular signaling cascade, learning or memory, negative regulation of cell proliferation, negative regulation of glucose import, negative regulation of heart contraction, negative regulation of insulin receptor signaling pathway, negative regulation of protein amino acid phosphorylation, negative regulation of protein kinase activity, negative regulation of translation, neutrophil chemotaxis, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation of exocytosis, positive regulation of inflammatory response, positive regulation of protein amino acid phosphorylation, positive regulation of smooth muscle cell proliferation, positive regulation of synaptogenesis, protein amino acid phosphorylation, regulation of muscle contraction, regulation of peptidyl-tyrosine phosphorylation, regulation of receptor-mediated endocytosis, regulation of the force of heart contraction, response to antibiotic, response to corticosterone stimulus, response to estradiol stimulus, response to ethanol, response to mechanical stimulus, response to organic cyclic substance, response to peptide hormone stimulus, response to reactive oxygen species, response to toxin
Cellular Components
cytoplasm, cytosol, membrane fraction, membrane raft, mitochondrion, nucleus, plasma membrane, protein complex, synaptosome
Literature References
- 11387207Ng T, Parsons M, Hughes WE, Monypenny J, Zicha D, Gautreau A, Arpin M, Gschmeissner S, Verveer PJ, Bastiaens PI, Parker PJ. Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility.EMBO J 2001 Jun 1;20(11):2723-41
- 10836144Sah VP, Seasholtz TM, Sagi SA, Brown JH. The role of Rho in G protein-coupled receptor signal transduction.Annu Rev Pharmacol Toxicol 2000;40:459-89
- 15541307Leitges M, Kovac J, Plomann M, Linden DJ. A Unique PDZ Ligand in PKCalpha Confers Induction of Cerebellar Long-Term Synaptic Depression.Neuron 2004 Nov 18;44(4):585-94 View 5538 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, calcium ion binding, calcium-dependent protein kinase C activity, diacylglycerol binding, kinase activity, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein kinase C activity, protein serine/threonine kinase activity, transferase activity, zinc ion binding
- Huntington's Disease Signaling
- Synaptic Long Term Depression
- Renin-Angiotensin Signaling
- NRF2-mediated Oxidative Stress Response
- CCR5 Signaling in Macrophages
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- IL-8 Signaling
- EGF Signaling
- Thrombin Signaling
- GNRH Signaling
- PPARα/RXRα Activation
- LPS-stimulated MAPK Signaling
- Corticotropin Releasing Hormone Signaling
- ERK/MAPK Signaling
- PDGF Signaling
- 14-3-3-mediated Signaling
- Apoptosis Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- Chemokine Signaling
- α-Adrenergic Signaling
- Natural Killer Cell Signaling
- Androgen Signaling
- Calcium-induced T Lymphocyte Apoptosis
- Hepatic Cholestasis
- Synaptic Long Term Potentiation
- Glioma Signaling
- fMLP Signaling in Neutrophils
- Xenobiotic Metabolism Signaling
- CCR3 Signaling in Eosinophils
- mTOR Signaling
- VDR/RXR Activation
- Prolactin Signaling
- G Beta Gamma Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- Axonal Guidance Signaling
- IL-3 Signaling
- Macropinocytosis Signaling
- HGF Signaling
- Mechanisms of Viral Exit from Host Cells
- IL-12 Signaling and Production in Macrophages
- Leukocyte Extravasation Signaling
- Endothelin-1 Signaling
- p70S6K Signaling
- RAR Activation
- CXCR4 Signaling
- Erythropoietin Signaling
- CREB Signaling in Neurons
- Virus Entry via Endocytic Pathways
- Growth Hormone Signaling
- Melatonin Signaling
- Aldosterone Signaling in Epithelial Cells
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Non-Small Cell Lung Cancer Signaling
- Caveolar-mediated Endocytosis Signaling
- VEGF Signaling
- FGF Signaling
- Neuregulin Signaling
- Thrombopoietin Signaling
- Type II Diabetes Mellitus Signaling
- Molecular Mechanisms of Cancer
- Factors Promoting Cardiogenesis in Vertebrates
- G-Protein Coupled Receptor Signaling
- Fc Epsilon RI Signaling
- NF-κB Activation by Viruses
Protein Domains
C1 domain, C2 domain, calcium dependent protein kinase C, hinge domain, hydrophobic domain, kinase, protein binding, Protein kinase, protein kinase C, protein serine/threonine kinase, V1 region
Subcellular Locations
axons, caveolae, cell body, cell periphery, cellular membrane, cytoplasm, cytoplasmic fraction, cytoskeleton, cytosol, cytosolic fraction, dendrites, detergent-insoluble fractions, detergent-soluble fraction, growth cone, matrix vesicles, membrane fraction, membrane/cytoplasmic fraction, mitochondrial fraction, nuclear fraction, nucleus, perinuclear region, perinuclear space, plasma membrane, sarcolemma, soluble fraction, synapse, synaptosomes
