PRKCI - protein kinase C, iota
Entrez Gene Name: protein kinase C, iota
Entrez GeneID: Human(5584)
, Mouse(18759), Rat(84006)
, Mouse(18759), Rat(84006) Synonyms: 2310021H13Rik, AI427505, APKC, aPKC lambda, DXS1179E, KIAA4165, MGC26534, mKIAA4165, nPKC-iota, PKC IOTA, PKC LAMBDA, Pkc lamda, Pkc lamda/iota, PKCI, PKCL, PRKCI, PRKCL
Gene Summary
- Human (5584): This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq]
- Rat (84006): member of the atypical subgroup of PKCs that do not contain the calcium binding domain and possess only one cysteine-rich region; plays a critical role in controlling cell growth and cell survival; enhances Rab2-mediated vesicle budding [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
actin filament organization, cell-cell junction organization, cellular response to insulin stimulus, cytoskeleton organization, establishment of apical/basal cell polarity, establishment or maintenance of epithelial cell apical/basal polarity, eye photoreceptor cell development, Golgi vesicle budding, intracellular signaling cascade, membrane organization, positive regulation of glucose import, protein amino acid phosphorylation, protein targeting to membrane, regulation of establishment of protein localization, secretion, vesicle-mediated transport
Cellular Components
apical part of cell, apical plasma membrane, cytoplasm, cytosol, endosome, membrane, nucleus, polarisome
Literature References
- 10836144Sah VP, Seasholtz TM, Sagi SA, Brown JH. The role of Rho in G protein-coupled receptor signal transduction.Annu Rev Pharmacol Toxicol 2000;40:459-89
- 15630019Govek EE, Newey SE, Van Aelst L. The role of the Rho GTPases in neuronal development.Genes Dev 2005 01 1;19(1):1-49
- 9858769Herdegen T, Leah JD. Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins.Brain Res Brain Res Rev 1998 Dec;28(3):370-490 View 3631 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, diacylglycerol binding, kinase activity, metal ion binding, nucleotide binding, phospholipid binding, protein binding, protein kinase activity, protein kinase C activity, protein serine/threonine kinase activity, transferase activity, zinc ion binding
- Virus Entry via Endocytic Pathways
- G Beta Gamma Signaling
- Cdc42 Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- HGF Signaling
- IL-3 Signaling
- IGF-1 Signaling
- GNRH Signaling
- Axonal Guidance Signaling
- Synaptic Long Term Depression
- α-Adrenergic Signaling
- fMLP Signaling in Neutrophils
- CXCR4 Signaling
- IL-12 Signaling and Production in Macrophages
- p70S6K Signaling
- Melatonin Signaling
- Erythropoietin Signaling
- Leukocyte Extravasation Signaling
- 14-3-3-mediated Signaling
- Aldosterone Signaling in Epithelial Cells
- Fc Epsilon RI Signaling
- Calcium-induced T Lymphocyte Apoptosis
- IL-15 Production
- Tight Junction Signaling
- Insulin Receptor Signaling
- Prolactin Signaling
- IL-8 Signaling
- Endothelin-1 Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- CCR5 Signaling in Macrophages
- mTOR Signaling
- Type II Diabetes Mellitus Signaling
- RAR Activation
- Macropinocytosis Signaling
- Growth Hormone Signaling
- ERK/MAPK Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Glioma Signaling
- Hepatic Cholestasis
- Synaptic Long Term Potentiation
- Androgen Signaling
- Huntington's Disease Signaling
- NF-κB Activation by Viruses
- Xenobiotic Metabolism Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- Molecular Mechanisms of Cancer
- CCR3 Signaling in Eosinophils
- Natural Killer Cell Signaling
- Thrombin Signaling
- Mechanisms of Viral Exit from Host Cells
- LPS-stimulated MAPK Signaling
- Thrombopoietin Signaling
- VDR/RXR Activation
- Renin-Angiotensin Signaling
- Neuregulin Signaling
- NRF2-mediated Oxidative Stress Response
- Corticotropin Releasing Hormone Signaling
- CREB Signaling in Neurons
Protein Domains
ATP binding, atypical protein kinase C, C1 domain, catalytic domain, kinase, PB1 domain, phospholipid binding, protein binding, Protein kinase, protein serine/threonine kinase
Subcellular Locations
cell periphery, cell-cell contacts, cellular membrane, cilia, cytoplasm, cytoplasmic fraction, cytoskeletal fraction, cytosol, cytosolic fraction, endosomes, junctional complexes, low-density microsomal fraction, membrane fraction, microsome, myoplasm, nucleus, plasma membrane
