CNP - 2',3'-cyclic nucleotide 3' phosphodiesterase
Entrez Gene Name: 2',3'-cyclic nucleotide 3' phosphodiesterase
Entrez GeneID: Human(1267)
, Mouse(12799), Rat(25275)
, Mouse(12799), Rat(25275) Synonyms: 2,3''-CYCLIC NUCLEOTIDE 3''-PHOSPHODIESTERASE, CNP, CNP1, CNPase, CNPF, CNPI, CNPII
Gene Summary
- Rat (25275): microtubule-binding protein that promotes microtubule assembly and may regulate cellular distribution of microtubules [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
adult locomotory behavior, axonogenesis, cyclic nucleotide catabolic process, microtubule cytoskeleton organization, RNA metabolic process, synaptic transmission
Cellular Components
cytoplasm, extracellular space, intracellular, intrinsic to membrane, melanosome, membrane, membrane fraction
Literature References
- 12590258Lappe-Siefke C, Goebbels S, Gravel M, Nicksch E, Lee J, Braun PE, Griffiths IR, Nave KA. Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination.Nat Genet 2003 Mar;33(3):366-74
- 16103231Lee J, Gravel M, Zhang R, Thibault P, Braun PE. Process outgrowth in oligodendrocytes is mediated by CNP, a novel microtubule assembly myelin protein.J Cell Biol 2005 Aug 15;170(4):661-73
- 16051705Zhang B, Cao Q, Guo A, Chu H, Chan YG, Buschdorf JP, Low BC, Ling EA, Liang F. Juxtanodin: An oligodendroglial protein that promotes cellular arborization and 2',3'-cyclic nucleotide-3'-phosphodiesterase trafficking.Proc Natl Acad Sci U S A 2005 Aug 09;102(32):11527-32 View 249 categorized literature findings and their references in IPA
Subcellular Locations
cell body, cellular membrane, cytoplasm, cytoskeleton, membrane processes, myelin enriched fraction, myelin sheath, myelin sheath inner loop, myelin sheath outer loop, paranodal loops, plasma membrane
