HTR2C - 5-hydroxytryptamine (serotonin) receptor 2C
Entrez Gene Name: 5-hydroxytryptamine (serotonin) receptor 2C
Entrez GeneID: Human(3358)
, Mouse(15560), Rat(25187)
, Mouse(15560), Rat(25187) Synonyms: 5-HT 2C RECEPTOR, 5-Ht receptor 2C, 5-HT2C, 5-HT2CR, 5-HTR2C, 5HT-1C, HTR1C, HTR2C, SR1
Gene Summary
- Human (3358): Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. [provided by RefSeq]
- Mouse (15560): Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in rodents show altered patterns of RNA editing in response to drug treatments and stressful situations. [provided by RefSeq]
- Rat (25187): Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in rodents show altered patterns of RNA editing in response to drug treatments and stressful situations. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of phospholipase C activity by serotonin receptor signaling pathway, activation of phospholipase D activity by G-protein coupled receptor protein signaling pathway, behavioral response to nicotine, feeding behavior, G-protein coupled receptor protein signaling pathway, G-protein signaling, coupled to cyclic nucleotide second messenger, inositol phosphate-mediated signaling, negative regulation of dopamine metabolic process, negative regulation of locomotion, organ regeneration, positive regulation of acetylcholine secretion, positive regulation of gamma-aminobutyric acid secretion, positive regulation of vasoconstriction, regulation of sensory perception of pain, response to drug, signal transduction, synaptic transmission
Cellular Components
cytoplasm, external side of plasma membrane, integral to membrane, membrane, nucleus, plasma membrane
Literature References
- 15502875John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets.PLoS Biol 2004 11 1;2(11):e363
- 12743035Gschwind A, Hart S, Fischer OM, Ullrich A. TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells.EMBO J 2003 May 15;22(10):2411-2421
- 12006486Bécamel C, Alonso G, Galéotti N, Demey E, Jouin P, Ullmer C, Dumuis A, Bockaert J, Marin P. Synaptic multiprotein complexes associated with 5-HT(2C) receptors: a proteomic approach.EMBO J 2002 May 15;21(10):2332-42 View 606 categorized literature findings and their references in IPA
Molecular Functions
G-protein coupled receptor activity, protein binding, receptor activity, serotonin binding, serotonin receptor activity, signal transducer activity
Protein Domains
carboxy terminal domain, G-protein coupled receptor, PDZ binding motif, protein binding, serotonin receptor
Subcellular Locations
apical membrane, axodendritic synapses, cell surface, cellular membrane, intracellular membranes, perinuclear membrane, plasma membrane, postsynaptic density, postsynaptic region, presynaptic dense projection, presynaptic regions
