E4F1 - E4F transcription factor 1
Entrez Gene Name: E4F transcription factor 1
Entrez GeneID: Human(1877)
, Mouse(13560), Rat(681359)
, Mouse(13560), Rat(681359) Synonyms: Dnase1l2, Dnase1l2 predicted, E4F, E4F1, MGC99614, P120E4F, Phi Ap3
Gene Summary
- Human (1877): The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
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Biological Process
cell cycle, cell division, cell proliferation, DNA replication, embryonic development, interspecies interaction between organisms, mitosis, modification-dependent protein catabolic process, regulation of growth, regulation of mitotic cell cycle, embryonic, regulation of transcription, regulation of transcription, DNA-dependent, transcription
Literature References
- 16882984Chagraoui J, Niessen SL, Lessard J, Girard S, Coulombe P, Sauvageau M, Meloche S, Sauvageau G. E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells.Genes Dev 2006 Aug 01;20(15):2110-20
- 14729613Fenton SL, Dallol A, Agathanggelou A, Hesson L, Ahmed-Choudhury J, Baksh S, Sardet C, Dammann R, Minna JD, Downward J, Maher ER, Latif F. Identification of the E1A-Regulated Transcription Factor p120(E4F) as an Interacting Partner of the RASSF1A Candidate Tumor Suppressor Gene.Cancer Res 2004 Jan 01;64(1):102-7
- 14645522Tessari MA, Gostissa M, Altamura S, Sgarra R, Rustighi A, Salvagno C, Caretti G, Imbriano C, Mantovani R, Del Sal G, Giancotti V, Manfioletti G. Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2.Mol Cell Biol 2003 Dec 01;23(24):9104-16 View 201 categorized literature findings and their references in IPA
Molecular Functions
DNA binding, ligase activity, metal ion binding, nucleic acid binding, protein binding, transcription coactivator activity, transcription corepressor activity, transcription factor activity, transcription regulator activity, zinc ion binding
Protein Domains
DNA binding, E4F DNA binding domain, N-terminal domain, protein binding, transcription co-activator, transcription co-repressor, transcription factor, transcription regulator, Zinc finger domain
