CD44 - CD44 molecule (Indian blood group)
Entrez Gene Name: CD44 molecule (Indian blood group)
Entrez GeneID: Human(960)
, Mouse(12505), Rat(25406)
, Mouse(12505), Rat(25406) Synonyms: AU023126, AW121933, AW146109, CD44, CD44 (containing exon 5), CD44 Antigen, CD44 STANDARD FROM, CD44A, CD44E, CD44R, CD44V7, CDW44, CSPG8, ECMR-III, Epican, HCELL, HERMES, Hermes antigen, IN, LHR, Ly-24, MC56, MDU2, MDU3, METAA, MGC10468, MGC124941, MIC4, MUTCH-I, Pgp-1, RHAMM, Splice isoform 1 of CD44 antigen precursor
Gene Summary
- Human (960): The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq]
- Rat (25406): adhesion molecule involved in migration, cell fusion and resportion in osteoclasts that also plays a role in cellular metastasis [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
blood vessel maturation, branching involved in ureteric bud morphogenesis, cell adhesion, cell migration, cell-cell adhesion, cell-matrix adhesion, healing during inflammatory response, inflammatory response, macrophage fusion, neuron projection development, positive regulation of neutrophil apoptosis, regulation of cell growth, response to organic cyclic substance, response to vitamin A
Cellular Components
apical plasma membrane, basolateral plasma membrane, cell surface, cytoplasm, external side of plasma membrane, extracellular matrix, focal adhesion, Golgi apparatus, integral to membrane, integral to plasma membrane, membrane, nucleus, plasma membrane, protein complex
Literature References
- 18362172McDonald B, McAvoy EF, Lam F, Gill V, de la Motte C, Savani RC, Kubes P. Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids.J Exp Med 2008 Apr 14;205(4):915-27
- 12464636Orian-Rousseau V, Chen L, Sleeman JP, Herrlich P, Ponta H. CD44 is required for two consecutive steps in HGF/c-Met signaling.Genes Dev 2002 Dec 1;16(23):3074-86
- 12145196Mori H, Tomari T, Koshikawa N, Kajita M, Itoh Y, Sato H, Tojo H, Yana I, Seiki M. CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain.EMBO J 2002 Aug 1;21(15):3949-59 View 3144 categorized literature findings and their references in IPA
Molecular Functions
binding, collagen binding, hyaluronic acid binding, phosphoprotein binding, protein binding, receptor activity
Protein Domains
cytoplasmic domain, extracellular domain, hyaluronan binding domain, hyaluronic acid binding, ligand-binding domain, protein binding
Subcellular Locations
actin filaments, apical cell surfaces, basolateral cell surfaces, basolateral membrane, cell periphery, cell surface, cellular membrane, cytoplasm, cytoplasmic face of plasma membrane, detergent resistant lipid raft fraction, detergent-insoluble fractions, filopodia, intracellular space, lamellipodia, membrane fraction, membrane rafts, membrane surface, nucleus, perinuclear region, perinuclear vesicles, pH resistant lipid raft fraction, plasma membrane, plasma membrane projections, ruffled borders, uropod, vesicles
