TRIM28 - tripartite motif-containing 28
Entrez Gene Name: tripartite motif-containing 28
Entrez GeneID: Human(10155)
, Mouse(21849), Rat(116698)
, Mouse(21849), Rat(116698) Synonyms: AA408787, FLJ29029, KAP-1, KRAB-ASSOCIATED PROTEIN 1, KRIP-1, MGC102100, RNF96, TF1B, TIF1B, TIF1BETA, TRIM28, XSG22
Gene Summary
- Human (10155): The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq]
- Rat (116698): mouse homolog is a transcriptional repressor; interacts with the Kruppel-associated box A (KRAB-A) domain of C2H2 zinc finger proteins [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
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Biological Process
epithelial to mesenchymal transition, negative regulation of transcription from RNA polymerase II promoter, negative regulation of transcription, DNA-dependent, positive regulation of gene-specific transcription, positive regulation of transcription, DNA-dependent, protein amino acid autophosphorylation, protein amino acid phosphorylation, regulation of transcription from RNA polymerase II promoter, regulation of transcription, DNA-dependent, transcription
Cellular Components
chromatin, intracellular, nuclear euchromatin, nuclear heterochromatin, nucleolus, nucleoplasm, nucleus
Literature References
- 16107876Wang C, Ivanov A, Chen L, Fredericks WJ, Seto E, Rauscher FJ, Chen J. MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation.EMBO J 2005 Sep 21;24(18):3279-90
- 12682018Li Z, Wang D, Na X, Schoen SR, Messing EM, Wu G. The VHL protein recruits a novel KRAB-A domain protein to repress HIF- 1alpha transcriptional activity.EMBO J 2003 Apr 15;22(8):1857-67
- 16169070Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE. A human protein-protein interaction network: a resource for annotating the proteome.Cell 2005 Sep 23;122(6):957-68 View 387 categorized literature findings and their references in IPA
Molecular Functions
metal ion binding, protein binding, protein kinase activity, sequence-specific DNA binding, transcription coactivator activity, transcription corepressor activity, transcription factor activity, transcription repressor activity, zinc ion binding
Protein Domains
B-box zinc finger domain, HP1 binding domain, PHD domain, protein binding, Protein kinase, RING domain, RING-B-box-coiled-coil domain, transcription co-activator, transcription co-repressor, transcription factor, transcription regulator, transcriptional repressor
Subcellular Locations
detergent-soluble fraction, interchromatin granule cluster fractions, nuclear fraction, nucleoplasm, nucleus
