AKT3 - v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
Entrez Gene Name: v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
Entrez GeneID: Human(10000)
, Mouse(23797), Rat(29414)
, Mouse(23797), Rat(29414) Synonyms: AI851531, AKT3, D930002M15Rik, DKFZp434N0250, PKB-GAMMA, PKBG, PRKBG, Protein kinase Akt-3, RAC-gamma, RAC-PK-gamma, STK-2
Gene Summary
- Human (10000): The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq]
- Rat (29414): kinase that associates with both protein kinase C subspecies and beta gamma subunits of G proteins [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cellular response to insulin stimulus, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation of sodium ion transport, protein amino acid phosphorylation, signal transduction
Literature References
- 16177823Hu Y, Yao J, Liu Z, Liu X, Fu H, Ye K. Akt phosphorylates acinus and inhibits its proteolytic cleavage, preventing chromatin condensation.EMBO J 2005 Oct 19;24(20):3543-54
- 15502875John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets.PLoS Biol 2004 11 1;2(11):e363
- 11959846Singh B, Reddy PG, Goberdhan A, Walsh C, Dao S, Ngai I, Chou TC, O-Charoenrat P, Levine AJ, Rao PH, Stoffel A. p53 regulates cell survival by inhibiting PIK3CA in squamous cell carcinomas.Genes Dev 2002 Apr 15;16(8):984-93 View 6989 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein kinase C binding, protein serine/threonine kinase activity, transferase activity
- Acute Phase Response Signaling
- Systemic Lupus Erythematosus Signaling
- Pancreatic Adenocarcinoma Signaling
- G-Protein Coupled Receptor Signaling
- Role of NFAT in Regulation of the Immune Response
- CREB Signaling in Neurons
- PTEN Signaling
- mTOR Signaling
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Erythropoietin Signaling
- Gα12/13 Signaling
- IGF-1 Signaling
- Renal Cell Carcinoma Signaling
- Type II Diabetes Mellitus Signaling
- Thrombin Signaling
- IL-12 Signaling and Production in Macrophages
- IL-3 Signaling
- Ceramide Signaling
- Amyloid Processing
- VEGF Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- IL-2 Signaling
- Chronic Myeloid Leukemia Signaling
- TR/RXR Activation
- iCOS-iCOSL Signaling in T Helper Cells
- Lymphotoxin β Receptor Signaling
- HIF1α Signaling
- Ephrin Receptor Signaling
- EIF2 Signaling
- NF-κB Activation by Viruses
- Sphingosine-1-phosphate Signaling
- Glioma Signaling
- IL-22 Signaling
- Relaxin Signaling
- Tight Junction Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Fc Epsilon RI Signaling
- JAK/Stat Signaling
- Huntington's Disease Signaling
- CXCR4 Signaling
- CTLA4 Signaling in Cytotoxic T Lymphocytes
- Nitric Oxide Signaling in the Cardiovascular System
- p53 Signaling
- AMPK Signaling
- Human Embryonic Stem Cell Pluripotency
- FXR/RXR Activation
- Wnt/β-catenin Signaling
- PXR/RXR Activation
- Endometrial Cancer Signaling
- Angiopoietin Signaling
- Prostate Cancer Signaling
- Insulin Receptor Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- CD28 Signaling in T Helper Cells
- Molecular Mechanisms of Cancer
- HGF Signaling
- Axonal Guidance Signaling
- Glucocorticoid Receptor Signaling
- G Beta Gamma Signaling
- PI3K/AKT Signaling
- IL-15 Signaling
- Dendritic Cell Maturation
- B Cell Receptor Signaling
- FAK Signaling
- Melanoma Signaling
- Colorectal Cancer Metastasis Signaling
- IL-4 Signaling
- Integrin Signaling
- GM-CSF Signaling
- ILK Signaling
- Acute Myeloid Leukemia Signaling
- 14-3-3-mediated Signaling
- HMGB1 Signaling
- FGF Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Neuregulin Signaling
- Amyotrophic Lateral Sclerosis Signaling
- TREM1 Signaling
- Myc Mediated Apoptosis Signaling
- NF-κB Signaling
- IL-17 Signaling
- RAR Activation
- Small Cell Lung Cancer Signaling
- IL-8 Signaling
- Natural Killer Cell Signaling
- p70S6K Signaling
- Non-Small Cell Lung Cancer Signaling
Protein Domains
carboxy terminal domain, kinase, pleckstrin homology (PH) domain, protein binding, protein kinase C binding, protein serine/threonine kinase
