ACTR1A - ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
Entrez Gene Name: ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
Entrez GeneID: Human(10121)
, Mouse(54130), Rat(294010)
, Mouse(54130), Rat(294010) Synonyms: ACTIN-RPV, ACTR1A, alpha-Arp1, ARP1, CENTROSOME ASSOCIATED ACTIN, CTRN1, FLJ52695, FLJ52800, FLJ55002
Gene Summary
- Human (10121): This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Literature References
- 11483508Hoogenraad CC, Akhmanova A, Howell SA, Dortland BR, De Zeeuw CI, Willemsen R, Visser P, Grosveld F, Galjart N. Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes.EMBO J 2001 08 1;20(15):4041-54
- 11461920Holleran EA, Ligon LA, Tokito M, Stankewich MC, Morrow JS, Holzbaur EL. beta III spectrin binds to the Arp1 subunit of dynactin.J Biol Chem 2001 Sep 28;276(39):36598-605
- 16254247Casenghi M, Barr FA, Nigg EA. Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome.J Cell Sci 2005 Nov 01;118(Pt 21):5101-8 View 74 categorized literature findings and their references in IPA
Subcellular Locations
astral microtubules, centrosome, cytoplasm, kinetochores, membrane fraction, microtubule aster fraction, myelin enriched fraction, pseudopodia, spindle fibers, spindle pole
