HTR1A - 5-hydroxytryptamine (serotonin) receptor 1A
Entrez Gene Name: 5-hydroxytryptamine (serotonin) receptor 1A
Entrez GeneID: Human(3350)
, Mouse(15550), Rat(24473)
, Mouse(15550), Rat(24473) Synonyms: 5-ht 1aR, 5-HT1A, 5-HT1A RECEPTOR, 5ht1a Inhibitory Autoreceptor, ADRB2RL1, ADRBRL1, Gpcr18, HTR1A, RAT5HT1A
Gene Summary
- Rat (24473): regulates AMPA receptor channels in the prefrontal cortex; regulation is mediated via inhibition of Ca2+/calmodulin-dependent kinase II [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
behavior, G-protein coupled receptor protein signaling pathway, inhibition of adenylate cyclase activity by serotonin receptor signaling pathway, positive regulation of cell proliferation, regulation of feeding behavior, serotonin receptor signaling pathway, signal transduction
Cellular Components
axon hillock, cell soma, integral to membrane, integral to plasma membrane, membrane, plasma membrane
Literature References
- 17540717Renner U, Glebov K, Lang T, Papusheva E, Balakrishnan S, Keller B, Richter DW, Jahn R, Ponimaskin E. Localization of the Mouse 5-Hydroxytryptamine1A Receptor in Lipid Microdomains Depends on Its Palmitoylation and Is Involved in Receptor-Mediated Signaling.Mol Pharmacol 2007 Sep 01;72(3):502-13
- 16033418Bauer A, Zilles K, Matusch A, Holzmann C, Riess O, von Hörsten S. Regional and subtype selective changes of neurotransmitter receptor density in a rat transgenic for the Huntington's disease mutation.J Neurochem 2005 Aug 01;94(3):639-50
- 14752100Turner JH, Gelasco AK, Raymond JR. Calmodulin Interacts with the Third Intracellular Loop of the Serotonin 5-Hydroxytryptamine1A Receptor at Two Distinct Sites: PUTATIVE ROLE IN RECEPTOR PHOSPHORYLATION BY PROTEIN KINASE C.J Biol Chem 2004 Apr 23;279(17):17027-37 View 692 categorized literature findings and their references in IPA
Molecular Functions
drug binding, G-protein alpha-subunit binding, G-protein coupled receptor activity, receptor activity, serotonin binding, serotonin receptor activity, signal transducer activity
Subcellular Locations
basolateral membrane, cell surface, cellular membrane, dendrites, perinuclear region, plasma membrane
