CHRNA4 - cholinergic receptor, nicotinic, alpha 4
Entrez Gene Name: cholinergic receptor, nicotinic, alpha 4
Entrez GeneID: Human(1137)
, Mouse(11438), Rat(25590)
, Mouse(11438), Rat(25590) Synonyms: ACRA4, ALPHA-4NACHR, BFNC, CHRNA4, EBN, EBN1, ENFL1, FLJ95812, NACHR, nAChR alpha-4, NACHRA4, NACRA4, NARAC
Gene Summary
- Human (1137): This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. [provided by RefSeq]
- Rat (25590): nicotinic acetylcholine receptor subunit responsible for binding calcium sensor protein visinin-like protein-1 (Vilip1), which modulates acetylcholine receptor expression and sensitivity [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
B cell activation, behavior, behavioral response to nicotine, calcium ion transport, cognition, DNA repair, ion transport, locomotory behavior, membrane depolarization, neurological system process, protein heterooligomerization, regulation of action potential, regulation of dopamine secretion, regulation of inhibitory postsynaptic membrane potential, regulation of membrane potential, response to hypoxia, response to nicotine, response to oxidative stress, sensory perception of pain, signal transduction, synaptic transmission, cholinergic, transport
Cellular Components
cell junction, cell soma, dendrite, external side of plasma membrane, integral to membrane, membrane, membrane fraction, nicotinic acetylcholine-gated receptor-channel complex, plasma membrane, postsynaptic membrane, synapse
Literature References
- 16738207Broad LM, Zwart R, Pearson KH, Lee M, Wallace L, McPhie GI, Emkey R, Hollinshead SP, Dell CP, Baker SR, Sher E. Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators.J Pharmacol Exp Ther 2006 Sep 01;318(3):1108-17
- 16014729Ren XQ, Cheng SB, Treuil MW, Mukherjee J, Rao J, Braunewell KH, Lindstrom JM, Anand R. Structural determinants of alpha4beta2 nicotinic acetylcholine receptor trafficking.J Neurosci 2005 Jul 13;25(28):6676-86
- 15213299Moretti M, Vailati S, Zoli M, Lippi G, Riganti L, Longhi R, Viegi A, Clementi F, Gotti C. Nicotinic Acetylcholine Receptor Subtypes Expression during Rat Retina Development and Their Regulation by Visual Experience.Mol Pharmacol 2004 Jul 01;66(1):85-96 View 756 categorized literature findings and their references in IPA
Molecular Functions
acetylcholine binding, acetylcholine receptor activity, drug binding, extracellular ligand-gated ion channel activity, ion channel activity, neurotransmitter receptor activity, nicotinic acetylcholine-activated cation-selective channel activity, protein binding, receptor activity
Protein Domains
acetylcholine receptor, carboxy terminal domain, extracellular ligand binding domain, ion channel, neurotransmitter-gated ion channel ligand binding domain, nicotinic acetylcholine-activated cation-selective channel, protein binding, transmembrane receptor
Subcellular Locations
axon terminals, cell surface, cellular membrane, cytoplasmic matrix, cytosol, dendrites, microtubules, perikaryon, plasma membrane, postsynaptic density, rough endoplasmatic reticulum
