DICER1 - dicer 1, ribonuclease type III
Entrez Gene Name: dicer 1, ribonuclease type III
Entrez GeneID: Human(23405)
, Mouse(192119), Rat(299284)
, Mouse(192119), Rat(299284) Synonyms: 1110006F08Rik, D12Ertd7e, DCR1, DICER, DICER1, HELICASE MOI, HERNA, K12H4.8, KIAA0928, mKIAA0928
Gene Summary
- Human (23405): This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
angiogenesis, branching morphogenesis of a tube, embryonic hindlimb morphogenesis, embryonic limb morphogenesis, gene silencing by miRNA, production of miRNAs, gene silencing by RNA, lung development, pre-microRNA processing, RNA interference, production of siRNA, RNA interference, targeting of mRNA for destruction, RNA processing, stem cell maintenance
Cellular Components
cytoplasm, Golgi apparatus, intracellular, nucleus, RNA-induced silencing complex
Literature References
- 17369401Murchison EP, Stein P, Xuan Z, Pan H, Zhang MQ, Schultz RM, Hannon GJ. Critical roles for Dicer in the female germline.Genes Dev 2007 Mar 15;21(6):682-93
- 12411504Provost P, Dishart D, Doucet J, Frendewey D, Samuelsson B, Radmark O. Ribonuclease activity and RNA binding of recombinant human Dicer.EMBO J 2002 Nov 1;21(21):5864-5874
- 17606634Schaefer A, O'carroll D, Tan CL, Hillman D, Sugimori M, Llinas R, Greengard P. Cerebellar neurodegeneration in the absence of microRNAs.J Exp Med 2007 Jul 09;204(7):1553-8 View 436 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, ATP-dependent helicase activity, double-stranded RNA binding, endonuclease activity, helicase activity, hydrolase activity, magnesium ion binding, manganese ion binding, metal ion binding, nuclease activity, nucleic acid binding, nucleotide binding, protein binding, ribonuclease III activity, RNA binding
Protein Domains
5' phosphomonoester producing endoribonuclease, DEAD box domain, double-stranded RNA binding, dsRNA-binding domain, enzyme, PAZ domain, protein binding, Ribonuclease III, Rnase 3 domain
