PRKCG - protein kinase C, gamma
Entrez Gene Name: protein kinase C, gamma
Entrez GeneID: Human(5582)
, Mouse(18752), Rat(24681)
, Mouse(18752), Rat(24681) Synonyms: MGC105487, MGC130440, MGC57564, PKC, PKC GAMMA, PKCC, PKCG, PKCI, Prkc, Prkcc, PRKCG, RATPKCI, SCA14
Gene Summary
- Human (5582): Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). [provided by RefSeq]
- Rat (24681): enriched in the neurons of the central nervous system and the spinal cord [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cell death, chemosensory behavior, intracellular signaling cascade, learning or memory, negative regulation of protein catabolic process, negative regulation of protein ubiquitination, positive regulation of mismatch repair, protein amino acid phosphorylation, synaptic transmission
Literature References
- 10836144Sah VP, Seasholtz TM, Sagi SA, Brown JH. The role of Rho in G protein-coupled receptor signal transduction.Annu Rev Pharmacol Toxicol 2000;40:459-89
- 16713569Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.Cell 2006 May 19;125(4):801-14
- 9857183Izumi Y, Hirata M, Hasuwa H, Iwamoto R, Umata T, Miyado K, Tamai Y, Kurisaki T, Sehara-Fujisawa A, Ohno S, Mekada E. A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.EMBO J 1998 Dec 15;17(24):7260-72 View 3434 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, calcium ion binding, diacylglycerol binding, kinase activity, metal ion binding, nucleotide binding, protein kinase activity, protein kinase C activity, protein serine/threonine kinase activity, transferase activity, zinc ion binding
- Calcium-induced T Lymphocyte Apoptosis
- Fc Epsilon RI Signaling
- IL-8 Signaling
- Thrombin Signaling
- IL-3 Signaling
- Melatonin Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Macropinocytosis Signaling
- G Beta Gamma Signaling
- NF-κB Activation by Viruses
- CCR3 Signaling in Eosinophils
- Prolactin Signaling
- Aldosterone Signaling in Epithelial Cells
- Type II Diabetes Mellitus Signaling
- Endothelin-1 Signaling
- Erythropoietin Signaling
- GNRH Signaling
- IL-12 Signaling and Production in Macrophages
- G-Protein Coupled Receptor Signaling
- α-Adrenergic Signaling
- Mechanisms of Viral Exit from Host Cells
- Thrombopoietin Signaling
- CXCR4 Signaling
- Axonal Guidance Signaling
- Corticotropin Releasing Hormone Signaling
- mTOR Signaling
- VDR/RXR Activation
- Glioma Signaling
- 14-3-3-mediated Signaling
- Molecular Mechanisms of Cancer
- LPS-stimulated MAPK Signaling
- Natural Killer Cell Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Leukocyte Extravasation Signaling
- CCR5 Signaling in Macrophages
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- HGF Signaling
- Growth Hormone Signaling
- Xenobiotic Metabolism Signaling
- fMLP Signaling in Neutrophils
- NRF2-mediated Oxidative Stress Response
- Cholecystokinin/Gastrin-mediated Signaling
- Synaptic Long Term Depression
- Synaptic Long Term Potentiation
- RAR Activation
- Neuregulin Signaling
- CREB Signaling in Neurons
- ERK/MAPK Signaling
- Factors Promoting Cardiogenesis in Vertebrates
- p70S6K Signaling
- Hepatic Cholestasis
- Huntington's Disease Signaling
- Renin-Angiotensin Signaling
- Virus Entry via Endocytic Pathways
- Androgen Signaling
Protein Domains
ATP binding, C1 domain, C2 domain, calcium ion binding, catalytic domain, hydrophobic domain, kinase, kinase domain, Protein kinase, protein kinase C, protein serine/threonine kinase, Transferase, V1 region
Subcellular Locations
axons, cell body, cell cortex, cellular membrane, cilia, cytoplasm, cytoplasmic vesicles, cytosol, cytosolic fraction, dendrites, lamellipodia, membrane fraction, membrane rafts, nucleus, perinuclear region, plasma membrane, soluble fraction, synaptosomes
