P2RX7 - purinergic receptor P2X, ligand-gated ion channel, 7
Entrez Gene Name: purinergic receptor P2X, ligand-gated ion channel, 7
Entrez GeneID: Human(5027)
, Mouse(18439), Rat(29665)
, Mouse(18439), Rat(29665) Synonyms: AI467586, MGC20089, P2RX7, P2X(7), P2X7, P2x7 receptor, P2X7R, Purinergic receptor
Gene Summary
- Human (5027): The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants which would encode different isoforms have been identified although some fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq]
- Rat (29665): an ATP receptor; may be involved in fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of MAPK activity, bleb formation, calcium ion transport, cation transport, cell death, cell morphogenesis, cell surface receptor linked signal transduction, cell volume homeostasis, cellular response to extracellular stimulus, ceramide biosynthetic process, collagen metabolic process, cytolysis, defense response to Gram-positive bacterium, gene expression, homeostasis of number of cells within a tissue, inflammatory response, ion transport, membrane budding, membrane depolarization, membrane protein ectodomain proteolysis, mitochondrion organization, multicellular organismal protein catabolic process, NAD transport, negative regulation of bone resorption, negative regulation of MAPKKK cascade, organic cation transport, oxygen and reactive oxygen species metabolic process, phagolysosome formation, phospholipid transfer to membrane, phospholipid translocation, plasma membrane organization, pore complex biogenesis, positive regulation of apoptosis, positive regulation of bone mineralization, positive regulation of calcium ion transport into cytosol, positive regulation of catalytic activity, positive regulation of cytokine secretion, positive regulation of cytolysis, positive regulation of cytoskeleton organization, positive regulation of gamma-aminobutyric acid secretion, positive regulation of glutamate secretion, positive regulation of interleukin-1 alpha secretion, positive regulation of interleukin-1 beta production, positive regulation of interleukin-1 beta secretion, positive regulation of interleukin-6 production, positive regulation of MAPKKK cascade, positive regulation of mitochondrial depolarization, positive regulation of ossification, positive regulation of prostaglandin secretion, positive regulation of protein amino acid phosphorylation, positive regulation of protein secretion, positive regulation of T cell mediated cytotoxicity, protein amino acid phosphorylation, protein oligomerization, protein processing, regulation of action potential in neuron, regulation of apoptosis, regulation of killing of cells of another organism, regulation of sodium ion transport, release of sequestered calcium ion into cytosol, response to ATP, response to bacterium, response to calcium ion, response to drug, response to electrical stimulus, response to fluid shear stress, response to lipopolysaccharide, response to mechanical stimulus, response to organic cyclic substance, response to organic substance, response to protein stimulus, response to zinc ion, sensory perception of pain, skeletal system morphogenesis, synaptic vesicle exocytosis, T cell homeostasis, T cell proliferation, transport
Cellular Components
bleb, cell soma, cell-cell junction, cytoplasm, external side of plasma membrane, integral to membrane, integral to nuclear inner membrane, integral to plasma membrane, membrane, membrane raft, neuromuscular junction, plasma membrane, synaptosome, terminal button
Literature References
- 17895406Dubyak GR. Go It Alone No More P2X7 Joins the Society of Heteromeric ATP-Gated Receptor Channels.Mol Pharmacol 2007 Dec 01;72(6):1402-5
- 14563321Seman M, Adriouch S, Scheuplein F, Krebs C, Freese D, Glowacki G, Deterre P, Haag F, Koch-Nolte F. NAD-induced T cell death: ADP-ribosylation of cell surface proteins by ART2 activates the cytolytic P2X7 purinoceptor.Immunity 2003 Oct 01;19(4):571-82
- 11707406Kim M, Jiang LH, Wilson HL, North RA, Surprenant A. Proteomic and functional evidence for a P2X7 receptor signalling complex.EMBO J 2001 11 15;20(22):6347-58 View 524 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, ATP-gated cation channel activity, channel activity, copper ion binding, ion channel activity, lipopolysaccharide binding, magnesium ion binding, protein binding, protein heterodimerization activity, protein homodimerization activity, protein serine/threonine kinase activator activity, purinergic nucleotide receptor activity, receptor activity, receptor binding, zinc ion binding
Protein Domains
ATP binding, ATP-gated cation channel, carboxy terminal domain, channel/pore class transporter, copper ion binding, ion channel, lipopolysaccharide binding, magnesium ion binding, protein binding, protein heterodimerization, purinergic nucleotide receptor, receptor, receptor binding, zinc ion binding
Subcellular Locations
cell body, cell surface, cell-cell contacts, cellular membrane, cytoskeletal fraction, cytosolic fraction, membrane fraction, myelin sheath, nuclear fraction, perinuclear region, plasma membrane, plasma membrane fraction, presynaptic terminals, synaptosomes
