FGF1 - fibroblast growth factor 1 (acidic)
Entrez Gene Name: fibroblast growth factor 1 (acidic)
Entrez GeneID: Human(2246)
, Mouse(14164), Rat(25317)
, Mouse(14164), Rat(25317) Synonyms: ACIDIC FGF, AFGF, Dffrx, ECGF, ECGF-beta, ECGFA, ECGFB, Fam, FGF, FGF-alpha, FGF1, FGFA, Fibroblast growth factor alpha, GLIO703, HBGF-1, HEPARIN BINDING ECGF, p40 SYT1
Gene Summary
- Human (2246): The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq]
- Rat (25317): may play a role in neurite outgrowth; may regulate cell differentiation in the nervous system; may act in synergy with fibronectin to enhance neuronal cell adhesion [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
anatomical structure morphogenesis, angiogenesis, cell differentiation, cell proliferation, fibroblast growth factor receptor signaling pathway, induction of an organ, lung development, multicellular organismal development, nervous system development, positive regulation of cell adhesion, positive regulation of epithelial cell proliferation, protein kinase cascade, signal transduction
Cellular Components
cytoplasm, extracellular region, extracellular space, nucleolus, nucleus, proteinaceous extracellular matrix
Literature References
- 12145206Skjerpen CS, Nilsen T, Wesche J, Olsnes S. Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity.EMBO J 2002 Aug 1;21(15):4058-69
- 15483628Fujimoto M, Izu H, Seki K, Fukuda K, Nishida T, Yamada S, Kato K, Yonemura S, Inouye S, Nakai A. HSF4 is required for normal cell growth and differentiation during mouse lens development.EMBO J 2004 10 27;23(21):4297-306
- 7688944Fantl WJ, Johnson DE, Williams LT. Signalling by receptor tyrosine kinases.Annu Rev Biochem 1993;62:453-81 View 1322 categorized literature findings and their references in IPA
Subcellular Locations
cell body, cell surface, cytoplasm, cytosol, extracellular space, membrane fraction, neurites, nuclear rim, nucleus, plasma, plasma membrane
