NQO1 - NAD(P)H dehydrogenase, quinone 1
Entrez Gene Name: NAD(P)H dehydrogenase, quinone 1
Entrez GeneID: Human(1728)
, Mouse(18104), Rat(24314)
, Mouse(18104), Rat(24314) Synonyms: AV001255, DHQU, DIA4, DTD, MGC93075, NAD(P)H dehydrogenase, quinone 1, Nadph dehydrogenase, NADPH DIAPHORASE, Nadph Quinone Oxidoreductase-1, Nadph-d, NMO1, NMOR1, NMORI, Nqo, NQO1, Ox-1, QR1, Quinone reductase
Gene Summary
- Human (1728): This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
- Rat (24314): enzyme that acts as an antioxidant; involved in increasing neuronal damage after injury [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
negative regulation of catalytic activity, nitric oxide biosynthetic process, oxidation reduction, positive regulation of neuron apoptosis, response to oxidative stress, response to toxin, synaptic transmission, cholinergic, xenobiotic metabolic process
Literature References
- 17545619Gong X, Kole L, Iskander K, Jaiswal AK. NRH:Quinone Oxidoreductase 2 and NAD(P)H:Quinone Oxidoreductase 1 Protect Tumor Suppressor p53 against 20S Proteasomal Degradation Leading to Stabilization and Activation of p53.Cancer Res 2007 Jun 01;67(11):5380-8
- 17360324Liu Y, Kern JT, Walker JR, Johnson JA, Schultz PG, Luesch H. A genomic screen for activators of the antioxidant response element.Proc Natl Acad Sci U S A 2007 Mar 20;104(12):5205-10
- 16920990Wan J, Diaz-Sanchez D. Phase II Enzymes Induction Blocks the Enhanced IgE Production in B Cells by Diesel Exhaust Particles.J Immunol 2006 Sep 01;177(5):3477-83 View 700 categorized literature findings and their references in IPA
Molecular Functions
coenzyme binding, cytochrome-b5 reductase activity, electron carrier activity, NAD(P)H dehydrogenase (quinone) activity, oxidoreductase activity
